After clearance from Institutional Ethics Committee of Government Ayurved college, Nagpur and CTRI Approval, A pragmatic open labelled study will be conducted on 24 subjects of Post COVID-19 Syndrome diagnosed by assessing Santarpanottha and Apatarpanottha will recruited from OPD,IPD, Casualty and periphery of Government Ayurved College, Nagpur.

               During the informed consent process the subjects will given enough time to read patient information sheet  and consent form.  subjects would also given freedom to ask the questions and all the questions would answered. If he/she agrees for participation in the study and if found fit to include during screening then he/she will recruited in the study. This visit called as screening visit.

           On screening visit, after written informed consent, screening of subject on the basis of clinical assessment for Santarpanottha and Apatarpanottha along with symptoms of Post COVID-19 Syndrome and fulfilling the diagnostic criteria . If all inclusion criteria is YES and all exclusion NO then subjects will be included on the basis of criteria given as BMI > 25 (Santarpanottha) and BMI<25 (Apatarpanottha) 

        Subjects would then undergo general and systemic examinations. Clinical symptoms of post COVID-19 Syndrome will assessed and recorded in the CRF. Study design will be pragmatic i.e., practical approach in our knowledge , No pragmatic trial has been conducted on Post COVID-19 Syndrome . Our hypothesis for this study is  Basti and Rasayana has effect on immunity and metabolism and can modulate Santarpanottha and Apatarpanottha types of pathological processes if two different types of approaches will be used.

Pachan ,Yog Bastikram and Rasayana treatment will be given in subjects assessed by clinically and divided in two group i.e,

 Duration of Basti:  08 days

  Duration of Rasayana : 21 days ( ½ Mandal)

  Time of administration:

       Gugglutiktak Kashay and Laghumalini Vasant will be given after the meals.

        Triphala kwath Niruh Basti and Brihatpanchmulsiddha Kshir Basti will be administered empty stomach.

         Tiltail and Kshirbala tail Anuvasan Basti will be administered after meals .

   Brahma Rasayan  Kalyanak Ghrit will be given on empty stomach

*Determinants of Dose:

          On the basis of Aatur Bal Pariksha Dose of Medicine will be finalized for each patient.

•        Range of dose for particular medicines are given in the table.

•        Dose of Basti will vary according to Aatur Bal Pariksha+ Basti Pratyagama

                                             Treatment details

  Subjects would be called to for follow up visits (i.e. 0^th, 5^th, 6-14^th, 35^th days respectively). On every follow up visits subjects undergoes general and systemic examinations ,assessment of clinical symptoms, assessment of scale and physical characters will be done on every follow up visit.

     Patient’s and Investigator’s global evaluations for overall improvement will be done on at the end of the study. Tolerability of the trial medicine will be assessed by the investigator and patient at the end of the study. All the patients would be closely monitored for any adverse events/ adverse drug reactions. All the investigations performed at the screening visit would be done  on 35^th day of the treatment.

      Based on the above study procedures observations would be made and recorded in the case record forms for each subject at every follow up. Subjects would be assessed for improvement in various  clinical symptoms scales of post COVID-19 Syndrome.

Following Scales will be used for various symptoms.

 1] FSS Scale                                                          

 2]MMRC dyspnea scale                           

 3]Chest pain scale                                                       

 4]VAS Scale                                          

 5]Smell and taste scale                      

 6]WOMAC scale                                               

 7]Hamilton depression scale                         

 8]Hamilton anxiety scale 

 9]Insomnia severity index 

10] Cough severity index 

11] Facial ageing scale 

12] Dizziness scale 

13] Pittsburge severity quality index 

14] Functional Status scale

15]Heart palpitation scale