Laparoscopic Cholecystectomy is a gold standard procedure for management of gall bladder stones and is usually performed under general anaesthesia. The procedure offers several advantages over open technique like reduction of stress response of surgery, decrease in post-operative pain, decrease chances of wound infection and faster recovery with good cosmetic appearance. Major disadvantages are due to physiological effects of insufflation of CO2 in the abdomen. Neuromuscular blocking agents are useful in performing endotracheal intubation and providing surgical relaxation. The onset time, duration of muscle relaxation and type of surgery are major factors that determine the choice of muscle relaxant to be used for the endotracheal intubation and surgical relaxation. Vecuronium was the first non-depolarizing neuromuscular blocking agent with an intermediate duration of action to be introduced into clinical practice. With both a shorter duration of action and minimum hemodynamic side effects, it set a standard against which all subsequent neuromuscular blocking agents were compared. Rocuronium, a non depolarising muscle relaxant, was first introduced and marketed in the United States. It is known for its rapid onset and intermediate duration of action.  Added advantage of Rocuronium is the rapid onset and it is excreted unchanged in urine, hence eliminating the side effects caused by the metabolites.

AIM: Comparison of hemodynamic changes in patients undergoing Laparoscopic  Cholecystectomy using Rocuronium and Vecuronium for intubation and maintenance under general anaesthesia.

OBJECTIVES:

1.To measure intubating condition

2.To measure hemodynamic changes during intubation

3.To measure hemodynamic changes during maintenance of general anaesthesia.

4.To record complications, if any.

The study will be conducted after obtaining clearance from the Institutional Ethical Committee and written informed consent from the patients. patients will be explained about the drugs being used in the in their own language and will also be explained that they can belong to either of the two groups. patients will be randomly divided in two groups by "chit and box" method. Control group will be given injection vecuronium 0.1mg/kg and study group will be given injection rocuronium 0.6mg/kg. 

Intubating conditions will be graded and assessed according to scoring of endotracheal intubating conditions by Cooper et al. Hemodynamic parameters : Heart rate, Blood Pressure, MAP and SPO2 will be recorded timely. Statistical analysis will be done using appropriate test.