Physiologic alterations due to surgical stress are widespread and affect all organ system of the body.¹ Of all these changes, the metabolic changes appear to be proportional to the severity of the surgical trauma with plasma cortisol and blood glucose concentration rising slightly during minor surgical procedures but significantly during major intraabdominal operations.² During surgery there is insulin resistance due to rise of levels of counter regulatory hormones like glucagon, growth hormone, cortisol and catecholamines which can be indirectly observed by the incidence of hyperglycemia.³

However, hyperglycemia is almost always detrimental, associated with increased morbidity and mortality even in nondiabetic patients^4-6. Several studies showed that hyperglycemia is a poor prognostic marker after traumatic brain injury.⁷ But none of these studies addressed the incidence of hyperglycemia in the perioperative period in non diabetic patients. 

The present study will be undertaken to know the prevalence of perioperative hyperglycemia in adult patients of traumatic brain injury undergoing craniotomy.

Specific objectives of the study:

1.      To know the intraoperative blood glucose levels in nondiabetic adult patients of TBI undergoing craniotomy in the perioperative period

2.      To know the blood glucose variability in these patients in the intraoperative period.

3.      To know the incidence of at least one episode of intra operative hyperglycemia.