A prospective, active-controlled, randomized, observer blind,comparative, parallel, 2-arm study will be conducted on 60 participants suffering from osteoarthritis of knee evaluate the efficacy and safety of a Myostaal liniment application.

Participant attending Orthopaedics OPD with a history of osteoarthritis knee and referred to physiotherapy OPD for physiotherapy, satisfying the selection criteria will be selected. All participants who voluntarily agree to participate and provide written informed consent for participation will be recruited in the study. Detailed personal, present and past medical history will be taken. Thorough physical examination, which includes vital variables, systemic examination, weight and demographics will be recorded and this will be called as a screening visit. Once the laboratory blood investigational reports satisfying the inclusion criteria are met, then these participants will be randomized into 2 different groups on Day 0. Group 1, will be given Myostaal liniment application along with physiotherapy for 90 days and Group 2 will be given physiotherapy only for 90 days. On day 0, Baseline WOMAC index score and VAS score, Lequesne severity index score, 5 times sit to stand test, 6 minutes’ walk test and single leg stance test will be done and baseline values will be recorded. All the participants will be given Tab Paracetamol 650mg (Tab. Paracip 650 mg) to be taken as and when required in case of severe pain.  All the patients will be asked to follow up in physiotherapy OPD on day 15, day 30, day 60 and day 90. At each visit, a complete physical examination will be done by the physician. The participants will be assessed for the WOMAC index score, VAS score, Lequesne severity index score, 6 minutes’ walk test, 5 times sit to stand test, single leg stance test and participant’s global assessment score and will be documented in CRF.