Proposed topic of research:

 EFFECTIVENESS OF PROPHYLACTIC NOREPINEPHRINE INFUSION IN PREVENTING HYPOTENSION FOLLOWING SPINAL ANESTHESIA IN CESAREAN SECTION – A PROSPECTIVE,RANDOMIZED ,DOUBLE BLIND STUDY.

Objective of the proposed research:

 To study and know about the efficacy of prophylactic infusion of  Norepinephrine in maintaining the systolicblood pressure within 20% of baseline following spinal anesthesia in parturientundergoing elective cesarean section.

Background of present study:

 Hypotension is the common complication of spinal anesthesia caused by the loss of systemic vascular resistance and leads to detrimental effects to both mother and foetus due to decrease in Uteroplacentaloutflow. Various vasopressors have been tried from Ephedrine to the Phenylephrine and Mephentermine with Phenyleprine being the gold standard. Now the search  for alternative vasopressor is focusedon Norepinephrine  because of its 𝛼-adrenergic and mild 𝛽-adrenergic effects. Effectiveness of prophylactic infusion of Norepinephrine in maintaining the blood pressure within 20% of the baselinewill be studied in this study.

Methodology :

This study is the Institution based , Prospective , Randomized, Double blinded study based on the healthy women undergoing elective cesarean section under spinal anesthesia in obstetrics operation room complexes of Midnapore Medical College & hospital. In this study total of  patients are taken and divided into two 100 groups with 50 in each group, in which one group receives prophylactic infusion of Norepinephrine (study group) and other receives prophylactic infusion of normal saline (control group).

Expected outcome:

we expect that administration of prophylactic Norepinephrine infusion will be very much helpful in maintaining the systolic blood pressure within 20% of the baseline following the spinal anesthesia and also there will be no remarkable detrimental effects on the Neonates which will be assessed by the APGAR scores and umbilical cord blood gas analysis.