World over, there has been an epidemic of COVID  19 cases with unexplained low respiratory infection caused due to novel coronavirus leading to severe acute respiratory syndrome.  Because of the suddenness in outbreak, no initial recommended treatments for COVID-19 were available and clinicians, world over, have been looking for new or existing options that can help guide prevention and treatment. A vaccine   generates a level of antibodies in the body.  The body’s immune system response to the vaccine can be done by   measuring the level of antibodies it has generated in the body.  AYUSH systems-based complementary and alternative medicine (CAM) have been traditionally used  as a treatment and preventive strategy for several diseases, including respiratory viral infections. Ministry of AYUSH   has issued an “Advisory on Coronavirus” to manage the COVID outbreak comprising of preventive and prophylactic symptom management of COVID-19   based on AYUSH systems of medicine   for immunity boosting and relieving the respiratory symptoms.   The advisory has   suggested AYUSH medicines as add on interventions to the conventional care  and have recommended multi-herbal Siddha concoction   Kaba Sura Kudineer as a symptom specific approach for prevention for fever and respiratory illness.  Its anti-inflammatory, antipyretic and antibacterial activity and its efficacy and safety  are  under study in reduction of SARS-CoV-2 viral load and reducing the onset of symptoms.   The present project is planned to measure the immune-modulating properties of the Covaxin - Covid-19 vaccine when provided along with Kabasura Kudineer by measuring the antibody response.