1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - For individual participant data meta-analysis.
   


5. By what mechanism will data be made available?
   Response (Others) -  THROUGH DIRECT EMAIL CONTACT


6. For how long will this data be available start date provided 01-11-2023 and end date provided 01-11-2028?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Peripheral Venous Cannulation (PVC) is an everyday practice in hospitals during which many patients experience pain and discomfort. It is a mandatory step during anaesthesia and in many other critical situations like resuscitation.Inadequate pain relief is not only unpleasant but may cause anxiety about further treatment deterring patients from seeking medical care in future.Topical anaesthetics applied locally to the vein before cannulation are non-invasive, well tolerated by patients and have been proven to be safe and efficacious.

Lidocaine is a synthetic amino ethylamide. It stabilizes the neuronal membrane by inhibiting ionic influxes required for the initiation and propagation of nerve impulses. A 5% lidocaine transdermal patch is available for topical analgesia. It comes as a single layer matrix patch which diffuses across the upper layers of the skin via passive diffusion from an area of high concentration to low concentration to produce an analgesic effect.

Ketoprofen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). It inhibits the activity of Cyclo-oxygenase (COX) 1 and 2 resulting in inhibition of prostaglandin and thrombaxane synthesis thereby decreasing the inflammatory response to cannulation and hence pain.Ketoprofen Transdermal patch when applied on the intact skin produces sufficient analgesia and has an advantage of minimizing thrombophlebitis due to its anti-inflammatory action.

Eutectic mixture of local anaesthetic (EMLA) Cream, a liquid emulsion is a eutectic mixture of the two amide local anaesthetics, namely Lidocaine 2.5% and Prilocaine 2.5%. When applied to the intact skin under occlusive dressing, EMLA cream releases lidocaine and prilocaine into the epidermal and dermal layers of the skin and provides analgesia by the accumulation of these anaesthetics in the vicinity of dermal pain receptors and nerve endings.A potential disadvantage of these topical agents could be the occurrence of erythema, induration or blanching at the site of their application.                                                                                                                                                                                                                      In the present study we seek to compare the analgesic efficacy of transdermal lidocaine 5% patch with transdermal ketoprofen patch and EMLA cream during PVC, as these modalities are easy to administer, non-invasive and with minimal adverse effects and drug interactions.