Polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhorea, infertility, and dysfunctional uterine bleeding) with or without presence of polycystic ovaries on ultrasound. Acanthosis  nigricans most commonly  observed in the neck and intertriginous areas such as armpit, groin and inframammary region⁷.PCOS is the most common female endocrinologic disorder,  in which ovaries become enlarged with many cysts which are in fact small undeveloped follicles. Over time there is thickening and fibrosis of the ovarian casing which prevents any follicles which do ripen from being released⁸. It has been considered a progressive multiglandular endocrinopathy where the balance of the hypothalamic pituitary adrenal ovarian axis is disturbed, resulting in failure of the cyclic reproductive mechanism⁹. Ovulatory dysfunction is typically indicated by unpredictable menses that occur at less than 21-day or greater than 35-day interval however, regular menses that occur every 21 to 35days¹⁰.

The Rotterdam criteria indicated PCOS to be present if any 2 of the 3 criteria are met.

1.Oligovulation/anovulation.

 2.Clinical and biochemical signs of hyperandrogenism.

3.Polycystic ovarian morphology(PCOM)seen on ultrasound¹¹.

To evaluate the menstrual flow PBAC a visual representation of blood loss is used¹².

SF-12 is a multipurpose short form survey with 12 questions, which are combined, scored, weighted to create two scales that provide glimpses into mental and physical functioning and overall health related quality of life¹³.

In unani system of medicine the disease has not been defined under the term of PCOS; as the disease has been discovered recently. The description of the disease has come under the heading of ‘Ihtibase al- Tamth’ ‘obesity’, phlegmatic disorder, uqr. Amenorrhoea mostly occurs in fair complexion and phlegmatic temperament female. According to Hippocrates and Galen a women with amenorrhoea develops masculine characteristic, male pattern of hair over the body, beard , hoarseness of voice,  mostly those female who are less muscular with prominent veins.¹⁴ Amenorrhoea which is caused by domination of khilte-balgham increases the viscosity. Leading to obesity then treat by mundij-i-balghum  and hot emmenagogue drugs such as maulusul and poste khyarshamber, mushktramashih,  persheoshan,  sudab, babuna¹⁵ etc which are widely used. Out of these compound formulation prepared with majeeth, saleekha ¹⁶is selected to prove its efficacy in PCOD, as this formula  possess the properties of musakkhin, mulattif, muhallil-i- awram , mudirr-i-bawl wa hayd, mufattih-i-sudad, muqawwi-i-mi’da wa jiger kasire-i-riyah, munaqiye-i- rhem ,munnaqiye-i jiger, munaffith-i-balgham, mu’arriq, muwalid-i- sheer.^4,5,6 The unani formulation is being more potent is selected for the study, in the management of PCOD scientifically.