1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response (Others) -  soundaryareddy13@gmail.com


6. For how long will this data be available start date provided 05-06-2021 and end date provided 05-06-2026?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - Nil

Alopecia areata is a dermatologic disease characterized in its limited form by circumscribed round or oval patches   of alopecia with well-demarcated borders between normal and affected scalp, there is no scale or induration of the scalp and no loss of follicular markings.¹

As per the recent statistical data, Alopecia areata affects 0.1 to 0.2% of human population. It occurs in bothmale and female. It is most common in children and early adults.

It is seen that an incidence of Alopecia areata tends to be higher when associated with diseases affecting the immune system affecting like asthma, allergies, atopic dermal aliments and hypothyroidism.

In modern system of medicine, the treatment for hair fall has been showing less encouraging results, management is with corticosteroids internally and externally. Minoxidile, UVR, laser therapy,hormonal therapy and hair transplantation,etc.

Even though this type of conventional management is effective, it has got some side effects and also the cost of these treatments are high. This is an attempt to find outa better, affordable and cost effective treatment for Indralupta which is also free from side effects.

Alopecia areata is correlated with Indralupta in Ayurveda. It is characterized by sudden loss of hair from scalp.

Pitta associated with Vata gets localized in the Roma kupa and causes the hair fall, later onKapha doshais  associated with Rakta causes the obstruction to the hair roots and restricts their re growth.²

Prachanna helps in clearing the obstructed romakupas and vitiated rakta is expelled out. Prachanna drains out the vitiatedblood from the srotas and later when lepa is applied over the region it facilitates easy and faster absorption of the drug. Lepa applied over the scalp will be absorbed by the hair follicle which causes the pore’s to open up and helps in the growth of healthy hair.

Ashtangahrudaya explains Daturapatra lepa for Indralupta in Shiroroga pratishedha adyaya³and Madhava chikitsa explains gokshuradhi lepa.⁴both the drugs are readily available and cost effective, hence chosen for the study.

HYPOTHESIS:

NULL HYPOTHESIS

H0 : There is neither effect of Prachanna with Gokshuradi lepa nor Dhatura patra lepain the management of indralupta.

ALTERNATE HYPOTHESIS :

H1 : Prachanna with Gokshuradi lepa has significant effect than Dhatura patra lepa in the management of indralupta.

H2 : Prachanna with Dhatura patra lepa has significant effect than Gokshuradi lepa in the management of indralupta.