Need for the study : Anemia is the most common and intractable nutritional problem in the world today. WHO has estimated that around 2 billion people across the world is suffering from Anemia. Anemia due to iron deficiency is the most prevalent type of Anemia. Iron Deficiency Anemia is one of the most prevalent forms of malnutrition. Globally, 50% of Anemia is attributable to iron deficiency and accounts for approximately 841,000 deaths annually worldwide. Africa and parts of Asia bears 71% of global mortality burden.  

The majority of iron deficiency is seen in growing children, adolescents, menstruating women, pregnant women and due to inadequate dietary intake of iron.  

As the name denotes the main feature of Panduroga is pandutva. Panduroga as mentioned in classics is a Pitta Pradana Vyadhi. According to Charaka it is one among the Rasavaha Srotodusti. Here there is Raktha Kshaya due to Pitta which reduces the Raktha Poshakamsha of Rasa. The signs and symptoms of Panduroga include Panduta, Shrama, Bhrama, etc. This description avails the correlation of Panduroga with Anemia in modern science. Iron deficiency Anemia is a disease that has similar symptoms Paleness, Weakness, Fatigue, constitutional symptoms, etiology and pathogenesis. 

Panduroga and Iron Deficiency Anemia have been studied in parallel to facilitate a better understanding of the disease and to devise a better management. This disease was chosen for the study due to its high incidence. Despite of many programs conducted by various organization and many medicines available for treating Anemia, it still remains as a burning nutritional problem. 

Oral iron salts are the most readily available way of replacing iron, ferrous sulphate is most effective and economical oral preparation. But about 10 – 20% patients will develop gastrointestinal side effects related to the ferrous sulphate these range from nausea, epigastric discomfort, vomiting, constipation and diarrhoea. Hence an attempt is made to compare the effect of Sammoha Loha over Ferrous Sulphate. 

With the reference of Rasendra Sara Sangraha Sammoha Loha is chosen for the present study. This is indicated in Panduroga and it contains drugs like Pippali, Maricha, Shunti, Chitraka, Amalaki, Vibhitaki, Hritaki, Vidanga, Lohabhasma, Abhrakabhasma and Ghrita. This has properties like bala, varna, agni vardhana, kamala, pandu rogahara, hridroga, shotahara, krimighna, hence the drug is chosen for the trial. Ferrous sulphate is taken as a standard drug for the comparison. 

Hypothesis :H0 - Sammoha Loha is not effective in Panduroga.  

H1 – Ferrous Sulphate is more effective in Panduroga than Sammoha Loha.  

H2 – Sammoha Loha is more effective in Panduroga than Ferrous Sulphate.