Personal protective equipments (PPE) are an essential requirement for health care workers in hospitals during rapidly spreading pandemic times of Sars CoV2, Influenza etc. Despite the protective function of the PPE, the effects of wearing the PPE – on the respiratory microclimate, respiratory functions and the individual sensations are equally important. Studies have reported subjective discomfort feeling, increased humidity and heat perception, increased breath resistance with respirator usages and also affect the wearer’s whole body thermal sensation, Prolonged hours of using the PPE, may lead to physiological stress on the wearer, causing headaches and making their regular tasks challenging. These effects might be due to the alterations in the respiratory microenvironment surrounding the masks. Different temperatures and humidification are induced on the outer and inner sides of the masks owing the differences in the permeability of air and water vapour in the type of PPE used. Following prolonged hours of donning the PPE, the physiological functions of the nasal cavity may change due to different temperature and humidification conditions within the PPE. Moreover, the frontline health care workers face a lot of mental stress owing to the unprecedented pandemic. Front-line HCWs often suffer from anxiety, stress related disorders, insomnia, depression, burnout, etc. The risk of exposure to infection, availability of personal protective equipment, job-related stress, perceived stigma and psychological impact of the isolation/quarantine and interpersonal distancing, effective risk communication to HCWs are some of the common socio-economic factors that play a major role in the stress response of the HCWs. Existing literature supports that pandemic, apart from causing mortality and physical morbidities, also leads to tremendous mental health problems in the sufferers as well as in the noninfected public. Despite the huge magnitude of mental health problems among the front-line HCWs, their psychological health is often overlooked.