The skin is extremely compound organ. It is the largest organ of our body. It is out of five ’Gnyanedriyas’ as described in Ayurvedic text. Which is responsible for touch sensation. It plays a vital role in general working of the body. Skin is the natural dressing on the body. It acts as an effective barrier against the entry of diseases. Patients of skin disease always physical, emotional and socio-economic embarrassment in the society. It is found to be the second most common cause for loss of work. In Ayurved, all the skin disease has been described under the umbrella of Kushtha. Eka-Kushta is one of the shudra kushtha described in Ayurvedic texts and it is Vata-Kaphaja in origin. Charaka has described three symptoms viz Asvednam, Mahavastum and Matsyashakalopamam of Eka-Kushtha. In the modern science ’Psoriasis’ disease is described. Eka-Kushtha can be compared with ’Psoriasis’ due to its maximum resemblance. Approximately 2-5% of the world suffer from this disease. Vagbhata has mentioned oral kushtaghna formulation in chikitsa sthan 19/37, from this formulation taking kutaja, chitraka, nimba, aragwadha, khadira, asana, saptaparna and added coconut oil we have prepared kutajadi taila. Nimba has kushtaghna property told in Bhavprakashnighantu guduachdivarga 94 therefor used in  Awagaha svedana. Emotional stress can be cured by Takradhara which is advised by Dr. Muss. Mahamanjishthadi Kashayam bears property of clearing channels of blood circulation of Psoriasis patch. In practice of Ayurved it is found that Combination of Abhyanga, Awagah and Takradhara is very effectively  cured Eka-Kushtha. Internal medicine Mahamanjishthadi kashayam along with these three treatments given to another group for comparative study. In present era there is no such medicine to cure Eka-Kushtha disease, therefore said research project is undertaken to check the Ayurvedic claims are justify or not.