Coronavirus (COVID-19) is a pandemic started from Wuhan City of  China in December 2019, with the case of Pneumonia with unknown cause later on in the mid of January 2020 it was declared as an emergency. There are Numerous studies have been published, establishing evidence and opinion-based guides current COVID-19 pandemic, which has taken the world by storm. The sudden outbreak of COVID-19 making society of the people realizes the threat of communicable diseases to human being. A whole-of-society approach is needed to tackle 21st century epidemics so that all the different type of epidemic disease is to be taken into consideration. Genetics and biological factors, ecology and the physical environment; are also affecting causes. This increasing convergence of many factors that requires multi-disciplinary, multi-sectoral and multi-faceted approaches. Ayurved can be helpful in pandemic disease like COVID-19. In COVID patients Cough and sputum, Chest tightness, Difficulty breathing, Fever, Fatigue, Nasal congestion, runny nose, Sick and vomiting are the common symptoms. Vyaghradi Kashaya is indicated in Vatshleshmak jwara having the symptoms like cough, running nose, breathlessness. Therefore, the proposed study is designed to search out the effectiveness of Vaghradi Kashay in asymptomatic and mild to moderate cases of COVID-19. The composition of the drug is Kantakari (Solanum xanthocarpum), Sunthi (Zingiber officinale), Amruta (Tinospora cordifolia), Pippali (Piper longum).These drugs have antiviral, antibacterial, antioxidant and immunomodulator property.