Percutaneous nephrolithotomy (PCNL) is commonly performed to treat the kidney stone. There are several effort has been done to minimise the postoperative pain such as multimodal analgesic regimens.^[1-3]  Ultrasound-guided erector spinae plane block (ESPB) is a novel interfascial paraspinal plane regional anesthesia technique, which was first used by Forero et al for the treatment of severe chronic thoracic neuropathic pain.^[4]. Although the majority of ESPBs described were in the thoracic region and few studies available for the lumbar region for postoperative analgesia.^[5]  The studies reported that it was an effective technique for postoperative analgesia in patients having ventral hernia repair ^[6], breast surgery ^[7], laparoscopic cholecystectomy procedures ^[8] and PCNL^{[9, 10]}. The peritubal infiltration along the renal capsule, subcutaneous tissue, skin and nephrostomy tube is carried out after PCNL is another effective method for postoperative analgesia.^[11] There was no reported study for comparison of ESPB versus peritubal infiltration for postoperative analgesia for PCNL. The aim of this randomized, controlled, single-blinded study was to compare the analgesic efficacy of ultrasound-guided ESPB versus peritubal infiltration versus no intervention.