Purpose of the Research:

Chronic Kidney Disease refers to an irreversible destruction of the kidney function persistent for more than or equal to3months.Prevalence of this disease is about 250 million people in the world.In India prevalence is about 800 per million population.The modern management of CKD  is worth costly and the ultimate remedy is renal transplantation.The increase in the prevalence of kidney disease progressing to End Stage Renal Disease and the consequent financial burden of renal replacement therapy create imbalance in the economy of Developing country like India.Moreover,main causes of CKD are Diabetes and Hypertension.By 2030,India is expected to have worlds largest population of patients  with Diabetes.So it’s a humble effort to find an alternate treatment for safe,effective as well as cheaper medication when compared to modern medicine.

The present study  aims to asses and compare the effect of Ayurvedic multi drug therapy along with Erandamooladi Basti in the management of Chronic Kidney Disease.

Information about Trial drug and Panchakarma procedure:

The trial drug includes Kashayam of Varuna Sigru(40ml two times daily ,before food),Gokshuradi Guggulu(two tab thrice ,before food),Guduchyadi Choornam(5gm twice,after food)and Gokshuradi Choornam(3gm twice before food) internally for 20-22 days.The Panchakarma procedure we are testing in this study is the Erandamooladi Basti(internal administration of medicated Basti dravya through anal route)for 16 days.The trial drug formulations used in this study are described in Ayurvedic classical texts and are prepared from the Pharmacy of Gujrat Ayurved University,Jamnagar and none of them has reported any side effects.We assure that this formulation has been prepared with complete care and purification methods if required.

Description of Research Process:

In the present study,participants which clinically diagnosed and confirmed cases of Chronic Kidney Disease will be divided in to two groups,with a minimum of 15 patients in each group.

Group A:

Participants willing to take Ayurvedic multi drug therapy and Erandamooladi Basti are included in Group A.The treatment protocol includes trikatu choornam 3-5gm for 3-5 days for improving digestive power,Gokshura,VarunaSigru kwath di guggulu,Guduchyadi Samana choornam,Gokshura choornam for 20-22days(doses as above mentioned).Panchakarma procedure includes internal administration of medicated Erandamooladi Basti dravya for 12days and Anuvasana Basti(using medicated thila thaila for 4 days) in the order of three Erandamooladi Basti (480ml)followed by one thila thaila Basti(60ml).

Group B:

Participants willing to take conventional medicine(Allopathic)medications are included in this group.The medications include AntiHypertensive drugs,drugs which reduces metabolic acidosis,Iron supplements,Vitamin B Complex medications,Calcium tablets etc.This group considered to be the standard controlled group.

Side Effects:

We will follow closely and keep track of any unwanted effects .Till now ,no side effects had been reported on  the internal administration of mentioned trial drugs and the administration of Erandamooiadi Basti procedure.

Benefits:

This project will help us to resolve the research question.There may not be any benefit for the society at this stage of the research,but future generations are likely to be benefitted,as it helps to find out proper treatment protocol for the management of Chronic Kidney Disease.

The information that we collect from this research project will be kept confidential,all outcomes will be noted in tabular form and appropriate statistical tests will be applied to compare the effect.