Nurses play a vital role in advocating and implementing infection control practices and it certainly requires some educational expertise, support from management and organizational policies. Little research has been undertaken in this aspect and in India, there is a lack of published research on infection control nurses in terms of numbers, qualification, roles and responsibilities. There is a need for the study to identify the existing structure of infection control nurses, their special education and their roles and responsibilities. Further, information from the present study may help to develop the strategy, policy or educational module for the infection control nurses. The current study will be a hospital-based exploratory survey conducted in Karnataka state, which will be conducted in two phases; Phase 1-survey to explore the existing structure and staffing pattern of infection control department and to identify factors affecting with infection control practices. In phase 2 Delphi will be conducted infection control nurses to bring about strategies to improve the Hospital Infection Control Practices. Expected study outcomes are to bring about a infection control module for the environmental and organizational structure of infection control department, staff requirements, basic education, opportunities for professional advancements, and training sessions for the healthcare workers hindering and favouring factors for the infection control nurses to work efficiently in the healthcare settings. Delphi from phase 2 among selected infection control nurses will be to find out problems and solutions for all the concerns pertaining to the infection control nurses in order to bring about a common guideline to all the hospital infection control nurses.