Allergic rhinitis is an inflammatory disorder of the nasal mucosa induced by allergen exposure triggering IgE-mediated inflammation. Clinically, it is characterized by four major symptoms–rhinorrhea, sneezing, nasal itching, and nasal congestion. It can also be associated with co-morbid conditions as Asthma, Atopic Dermatitis & Nasal polyps. Around 20–30 % of the Indian population suffers from allergic rhinitis and that 15 % develop asthma. Allergic Rhinitis symptoms result in sleep disturbance, fatigue, depressed mood and cognitive function compromise that impairs quality of life and productivity. 

A number of pharmacologic interventions are prescribed to treat Allergic Rhinitis. Intranasal corticosteroids (INC) are recommended in current guidelines as first-line therapy for patients with moderate to severe Allergic Rhinitis, particularly when nasal congestion is the prominent symptom.

Preservatives in the INC formulation may produce nasal irritation and  may impart unacceptable taste or odour to the formulation. Further, the relative osmotic pressure or tonicity of the formulation can modulate nasal retention and absorption, thereby potentially influencing clinical efficacy.¹ The use of INC may tend to cause adverse effects like a stinging or burning sensation in the nose, dryness and crustiness in the nose, a dry, irritated throat, an unpleasant taste in the mouth, itchiness, redness and swelling in the nose, nosebleeds, etc., Furthermore INC could relieve the Nasal Congestion only that too for a limited time period. They don’t play a role in modulating the immunity of the patient, Prevention or Cure of the Allergic Rhinitis.

 The Diagnosis of Allergic Rhinitis is based on Typical history of allergic symptoms ‘‘sneezers and runners’’. All patients with persistent allergic rhinitis need a nasal examination (Anterior rhinoscopy, Nasal endoscopy). The diagnostic tests are directed towards the detection of free or cell bound IgE. Immediate hypersensitivity skin tests are widely used to demonstrate an IgE-mediated allergic reaction. These represent a major diagnostic tool in the field of allergy. The measurement of allergen-specific IgE (radioallergosorbent testing, RAST) in serum is of importance and is of similar value to skin tests. They are more useful in patients having dermatitis, dermographism, and in cases where antihistamines have to be continued during testing.

Various Clinical Trials conducted by ‘CCRH, New Delhi’ and other reputed institutions across globe have demonstrated the efficacy of Homoeopathic management of Allergic Rhinitis. Homoeopathic Medicines like Allium cepa, Sabadilla, Aurum triphyllum, Euphrasia, Hepar sulphuris, Arsenicum iodatum, Kalium iodatum, etc., are found to be effective in treating Allergic Rhinitis by Previous Studies.

Lesser known drugs like Galphimia glauca.6C, Luffa operculata.6C & Penthorum Sedoides.6C are also found to be clinically effective in treating Allergic Rhinitis by literature survey. But their effect on modulation of Elevated Serum Immunoglobulin-E levels in Allergic Rhinitis patients is not yet explored by any of the Researches across the World.

These details intended me to do a comparative experimental study on the effectiveness of the three said medicines in the modulation of Serum Immunoglobulin-E levels in Allergic Rhinitis patients.