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CTRI Number  CTRI/2020/01/023046 [Registered on: 30/01/2020] Trial Registered Prospectively
Last Modified On: 22/06/2022
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Preventive 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Evaluation of tooth filling without drilling 
Scientific Title of Study   Clinical effectiveness of Chemomechanical versus Conventional caries removal for alternative restorative treatment. 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Saloni Gupta 
Designation  Post graduate  
Affiliation  Manipal Academy of Higher Education 
Address  Manipal college of Dental Sciences, Department of Public Health Dentistry, room number: 08, Manipal
Manipal college of Dental Sciences, Department of Public Health Dentistry, room number: 08, Manipal
Udupi
KARNATAKA
576104
India 
Phone  7389565652  
Fax    
Email  saloni.gupta654@gmail.com  
 
Details of Contact Person
Scientific Query

Modification(s)  
Name  Dr Shashidhar Acharya 
Designation  MDS 
Affiliation  Manipal Academy of Higher Education 
Address  Manipal College of Dental Sciences, Department of Public Health Dentistry, room number:08, Manipal
Manipal College of Dental Sciences, Department of Public Health Dentistry, room number:08, Manipal
Udupi
KARNATAKA
576104
India 
Phone  9448127031  
Fax    
Email  sh.acharya@manipal.edu  
 
Details of Contact Person
Public Query
 
Name  Dr Saloni Gupta 
Designation  Post graduate  
Affiliation  Manipal Academy of Higher Education 
Address  Manipal College of Dental Sciences, Department of Public Health Dentistry, room number: 08, Manipal
Manipal College of Dental Sciences, Department of Public Health Dentistry, room number: 08, Manipal
Udupi
KARNATAKA
576104
India 
Phone  7389565652  
Fax    
Email  saloni.gupta654@gmail.com  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Dr Saloni Gupta 
Address  Manipal College of Dental Sciences, Department of Public Health Dentistry, room number:08, Manipal 
Type of Sponsor  Other [Private Dental College] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Saloni Gupta  MCODS, Manipal  Room number 8, Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal
Udupi
KARNATAKA 
7389565652

saloni.gupta654@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied
Modification(s)  
Health Type  Condition 
Healthy Human Volunteers  class1 caries 
Patients  (1) ICD-10 Condition: K025||Dental caries on pit and fissure surface,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Group 1  Chemomechanical caries removal using Carie care as per manufacturer instructions followed by alternative restorative treatment using Fuji IX restorative material. 
Comparator Agent  Group 2   Group 2 will receive conventional caries removal using excavators followed by alternative restorative treatment using Fuji IX restorative material. Success of the restoration would be evaluated at 1, 6 and 12 months using ART assessment criteria (scores 0, 1 and 7). 
 
Inclusion Criteria  
Age From  6.00 Year(s)
Age To  15.00 Year(s)
Gender  Both 
Details  Children aged 6-15 years, with one or more than one cavitated carious lesions, single surface, occlusal load bearing area, which are be accessible to hand instruments in permanent
dentition. Consent given by children and their parents are included  
 
ExclusionCriteria 
Details  Presence or history of pain/abscess/fistula/swelling near to the
carious tooth.
ï‚· Deep carious lesions exposing pulp of tooth.
ï‚· Presence of tenderness on percussion.
ï‚· Children with syndromes, undergoing orthodontic treatment,
developmental defects of teeth, or any other conditions that
contraindicate the caries excavation/restorations. 
 
Method of Generating Random Sequence   Stratified block randomization 
Method of Concealment   Not Applicable 
Blinding/Masking   Participant and Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
Success of the restoration would be evaluated at 1, 6 and 12 months  Success of the restoration would be evaluated at 1, 6 and 12 months 
 
Secondary Outcome  
Outcome  TimePoints 
Success of the restoration would be evaluated at 1, 6 and 12 months  Success of the restoration would be evaluated at 1, 6 and 12 months 
 
Target Sample Size   Total Sample Size="82"
Sample Size from India="82" 
Final Enrollment numbers achieved (Total)= "82"
Final Enrollment numbers achieved (India)="82" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   30/01/2020 
Date of Study Completion (India) 22/10/2021 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   Nil 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Brief Summary  
Aims : To assess the clinical effectiveness of Chemomechanical
versus Conventional caries removal for alternative restorative
treatment (ART).
Objectives:
 To compare the success of the restorations at 1, 6 and 12
months between the groups.
To compare the time taken and pain reaction measured by
the Sound, Eye, and Motor scale (SEM) between the
groups.
Justification for study (whether of national significance with
rationale) :
Chemomechanical caries removal technique provides less anxiety
and more clinical acceptance thus instilling a positive attitude
towards dental treatment in a person. This study would also
provide information regarding the efficacy of newer caries
removal techniques that can be used in community or field
settings.
Departments involved: Department of Public Health Dentistry,
Manipal college of Dental Sciences, Manipal.
Study period: 18 months
Sample size: G-power software, 82 (With the effect size of 0.5,
power of 95% and significance level of α=0.05, yielded a sample
size of 52. Considering an attrition of 20%, we inflated the sample
size to 82.)
Materials and methods:
a) Inclusion criteria:
 Children aged 6-15 years, with one or more than one cavitated
carious lesions, single surface, occlusal load bearing area,
which are be accessible to hand instruments in permanent
dentition.
 Consent given by children and their parents are included.
b) Exclusion criteria :
 Presence or history of pain/abscess/fistula/swelling near to the
carious tooth.
 Deep carious lesions exposing pulp of tooth.
 Presence of tenderness on percussion.
Children with syndromes, undergoing orthodontic treatment,
developmental defects of teeth, or any other conditions that
contraindicate the caries excavation/restorations.
c) Biological materials required (type - blood, tissue etc and
quantity): Nil
d) Statistical methods: Intergroup comparisons would be done
with chi-square test/ Student t-test
9. Detailed description of procedure / processes:
School children would be screened based on inclusion and
exclusion criteria. Eligible children and their parents would be
approached for consent and participation in the study. Children
would be randomized into Group I and Group II based on the block
randomization.
 Group 1 will receive Chemomechanical caries removal using
Carie care as per manufacturer instructions followed by
alternative restorative treatment using Fuji IX restorative
material.
 Group 2 will receive conventional caries removal using
excavators followed by alternative restorative treatment using Fuji IX restorative material.
evaluated at 1, 6 and 12 months (scores 0, 1 and 7)
11. Potential risks: Children may experience mild discomfort
during excavation of caries.
Benefits: Treatment of caries at early stages prevents further
progression of the disease.
12. Ethical considerations and methods to address issues :
Informed consent, indirect identifiers for maintaining
confidentiality. Patient may experience pain which might
require root canal treatment. Camp cards will be provided to
avail the necessary treatment at subsidized rates.
13. Budget : 12,100
 
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