Madhumeha is a clinical entity described in Ayurveda as one of the types of Vataja Prameha. Regarding this disease Ayurvedic scholars have mentioned that Madhumeha is caused by aggravation of Vata, the patient passes excess urine which is sweet, astringent in taste, slightly turbid and pale in color. Describing the Prameha, the cardinal feature of Prameha has been mentioned as Avile Prabhuta Mutrata. Madhumeha is caused by Dhatukshaya manifests as thin and asthenic individual due to loss of Oja or imbalance in Oja. In Margavaranjanya Madhumeha the vitiated Kapha and Meda obstruct the passage of Vata. The obstructed Vata is vitiated again and carries Ojas to Basti thus manifests Madhumeha.

 Madhumeha can be correlated with a similar disease described in modern medical sciences as Diabetes mellitus, which is a syndrome with disordered metabolism and inappropriate hyperglycemia, due to either a deficiency of insulin secretion or to a combination of insulin resistance and inadequate insulin secretion to compensate. Diagnostic emphasis then shifted to the glucose levels themselves and in addition to diabetes a milder level of hyperglycemia denoted impair glucose tolerance has been defined by the W.H.O.

Aim is to compare the Hypoglycaemic effect of Haridra Churna and Chandraprabha Vati in Madhumeha (Type 2 Diabetes Mellitus) along with Pippali Churna as adjuvant. Objectives are to evaluate the effectiveness of Haridra Churna along with Pippali Churna as adjuvant in Madhumeha (Type 2 Diabetes Mellitus), To evaluate the effectiveness of Chandraprabha Vati along with Pippali Churna as adjuvant in Madhumeha (Type 2 Diabetes Mellitus), To compare the hypoglycemic effect of Haridra Churna and Chandraprabha Vati in Madhumeha (Type 2 Diabetes Mellitus) along with Pippali Churna as adjuvant.

Study design is Single centred, Open label, Comparative Study, Randomized control study, Efficacy study, with one of active control without any crossover. Study area is OPD & IPD of Ch. Brahm Prakash Ayurveda Charak Sansthan, Khera Dabar, New Delhi. Study population is Diagnosed patients of Type-2 Diabetes Mellitus will be selected for this purpose on the basis of inclusion criteria. Detail of drug administration is  Haridra Churna– In dosage of 3gm twice in a day for 21 days with ‘Pippali Churna’ 500mg half an hour before meal in Group A (Trial group). Chandraprabha Vati– in dosage of 500 mg twice in a day for 21 days with ‘Pippali Churna’ 500mg half an hour before meal in Group B (Comparator group). 

Inclusion criteria involves 1. Patients with age between 40-60yrs. 2. Sex: Both male and female. 3. Patients fulfilling the diagnostic criteria for Diabetes Mellitus framed by the AMERICAN DIABETES ASSOCIATION. 3. FBS-126-200mg/dl PPBS-150-350 mg/dl. 4. HbA1c 7% and more. Patients taking any type of oral anti-diabetic treatment from 1. Biguanides and 2. Sulfonylurea. Exclusion criteria involves 1. Patients below the age of 40 years and more than the age of 60 years, 2.  Fasting Blood Sugar Level <126 mg/dl and >200 mg/dPost Prandial Blood Sugar Level <180 mg/dl and >350 mg/dl 3. HbA1c <7%, 4. Patients depending on the insulin for blood glucose control, 5. Patients with diabetic complications, 6. Patients suffering from Secondary Diabetes, 7. Gestational diabetes, 8.     Pregnant ladies and lactating mothers. Assesment criteria involves SUBJECTIVE criterias are 1. Prabhootmutrata, 2. Avilamutrata, 3. Mutra Madhuryata, 4. Swapnasheela, Aasansheela, Atikshudha, Atisweda, Daurbalya, Atitrushna. Objective criteria involves 1. FBS AND PPBS, 2. Urine (Routine and Microscopic)

Patients will be clinically assessed on day 0,1,7,14,21 days for efficacy and findings would be noted in specified proforma and follow up of the subjects will be done after 21 days the Haridra Churna with ‘Pippali Churna’ has been administered. The response of the patient’s diseased condition will be observed and recorded before, during and after the treatment in a specially designed case proforma includes detailed history, physical examination, laboratory investigations and assessment based on subjective and objective parameters for which appropriate scoring pattern is adopted.Total duration of study is 42 Days. Duration of Haridra churna administration is 21 day. Follow up will be done on 42^nd day