Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss.The role of Porphyromonas gingivalis is well established in the development and pathogenesis of periodontitis.Minocycline acts by interfering with protein synthesis in the bacterial cell wall along with its anti-collagenase effect.Diode laser accelerates wound healing, promotes angiogenesis and also augments growth factor release.

This Randomized Clinical Trial protocol is designed as a split mouth single masked clinical trial of 12 weeks duration simulating the treatment flow of conventional periodontal therapy. After qualifying for the study, 15 patients age ranging from 30-65 years will be enrolled and 4 clinical variables along with the microbiological samples will be evaluated at the baseline by one examiner who will be recording all measurements in a single blind design. This will include Sulcus Bleeding Index (SBI)Plaque Index (PI), Probing Pocket depth (PPD), Clinical Attachment Level (CAL) along with subgingival plaque samples for Porphyromonas Gingivalis. Full mouth scaling and root planing will be performed at baseline appointment following initial examination.One quadrant will receive the diode laser therapy on the 1^st, 3rd and the 7^th day after scaling and root planing. The other will receive minocycline gel application after scaling and root planing and the gel application will be repeated at two and four weeks in the test sites, according to the manufacturer’s instructions.Subgingival plaque samples will be collected at baseline, and at three month intervals. Sterile periodontal curette will be used for collection of subgingival plaque samples.For sample collection the teeth surfaces will be dried with sterile gauze to avoid contamination by saliva. Sub gingival plaque samples will be collected from deepest periodontal pockets using sterile periodontal curette and assessed for the microbial load using Polymerase chain reaction

This study is done to compare the efficacy of minocycline as local drug delivery and diode laser debridement and also to evaluate the levels of Porphromonasgingivalisin chronic periodontitis patients.