In Prameha all the dravadhatus in reference to kapha from shareera gets excreted through mutra. There is a significant change in physical constitution, chemical contents and biochemical properties in such mutra. The abnormal metabolic admixture of dustadosha, pradushtadhatu with mutra is nothing but pradusthita mutra or saama mutra. Therefore there is a extra addition of ama and its constituents to mutra which make mutra turn avila.

Normal value of GFR is 125ml/min. A stepwise increase in nitrogenous constituents of blood like urea, creatinine etc and other biochemical parameters like albumin, electrolytes etc also believed to reflect deteriorating kidney function.

Renal involvement is a common complication and a leading cause of death in diabetes which is classified under late systemic complications.

In chirakaaleena Pramehi dhatu excreted out with mutra can be considered as samala mutrata or saghana mutrata which signifies the reduced GFR by kidneys landing up in many renal dysfunctions.Since Cystatin-C is a small protein which is produced constantly, freely filtered by glomerulus and also fully reabsorbed and broken down by renal tubules is considered as better marker for GFR than Serum Creatinine.

In this research study the findings of Cystatin-C will help in understanding the relation between duration of Prameha vyadhi and Renal dysfunctions occurring in the same which will help in analyzing the involvement of mutravaha srotas.