According to Ayurveda “Rogaah Sarvepimandagou” means all the diseases are caused by mandagin ((digestive fire or various enzymatic process involved in digestion, absorption and metabolism at various level) which causes improper digestion of ingested nutrients (food) leading to formation or accumulation of Amadosha (intermediate products/or toxins) which produces its effect locally or generalized) .Grahani (middle part of amasaya and pakwasaya) is the place of Jatharagin. When the digestive power of grahani became less due to the improper food habits and stressfull life style. It causes Grahani roga which is known as Grahani in Ayurveda. In general, the digestion and absorption of food materials can be divided into 3 major phases: Luminal, Mucosal and Post - absorptive phases. The luminal phase in which di fats, proteins, and carbohydrates are hydrolyzed and solubilised by secreted digestive enzymes and bile can be considered to be the role of Pachaka Pitta which is responsible for the breakdown and synthesis of substances i.e. catabolic and anabolic activities. Mucosal phase relies on the integrity of the brush-border membrane of intestinal epithelial cells to transport digested products from the lumen into the cells is compared to Kledaka Kapha by  the virtue of its cooling property which  counter the heating property of Pitta.  In modern medicine, the disease can be co-related with malabsorption syndrome and also Irritable Bowel Syndrome. There are enormous formulations mentioned in Ayurvedic classics for the augmentation and restoration of Agnibala in general and Grahani in particular.Jatiphaladya Churna & Chitrakadi gutika are reputed formula, though mentioned in the Sarangadhara Samhita and Charaka Samhita respectively in Ayrveda classics, for the treatment of Grahani, Atisara, Agnimandya etc.

      As grahani roga is caused due to agnimandya, the main line of treatment is to correct the agnidusti by administering drugs which are deepana and pachana in action. The trial durgs like Jatiphaladi Churna and Chitrakadi Gutika are  classical medicines formulated by Achary Charak and Acharya Sarangadhara.Which are referred to AFI,Part-I, 7:12. and AFI,Part-I, 12:11. The Ingredients which these trial medicines are  contains, having properties like deepan, pachana and sthambhaka and can able to correct the agnimandya condition and disordered of purishavaha stoats.

      So  the aim and object of the present study is planned to evaluate therapeutic efficacy of Jatiphaladi Churna and Chitrakadi Gutika in the patients of Grahani along with safety measures by observing adverse events (AE) if any or Adverse drug reaction (ADR). The efficacy of these drugs would be assessed by observing the improvement in Subjective parameters (Clinical Symptoms). Improvement in WHOQOL score and lab parameters.