According to Ayurveda “Rogaah Sarvepi mandagnou sudaramudarani cha” means all the diseases are caused by mandagni ((digestive fire or various enzymatic process involved in digestion, absorption and metabolism at various level) which causes improper digestion of ingested nutrients (food) leading to formation or accumulation of Amadosha (intermediate products/or toxins) which produces its effect locally or generalized) .Grahani (middle part of amasaya and pakwasaya) is the place of Jatharagni. When the digestive power of Grahani become weaken due to the improper food habits and stress full life style, It causes Grahani roga which is also known as Grahani in Ayurveda. In general, the digestion and absorption of food materials can be divided into 3 major phases: Luminal, Mucosal and Post - absorptive phases. The luminal phase in which the fats, proteins, and carbohydrates are hydrolyzed and solubilized by secreted digestive enzymes and bile can be considered to be the role of Pachaka Pitta which is responsible for the breakdown and synthesis of substances i.e. catabolic and anabolic activities. Mucosal phase relies on the integrity of the brush-border membrane of intestinal epithelial cells to transport digested products from the lumen into the cells is compared to Kledaka Kapha by  the virtue of its cooling property which  counter the heating property of Pitta.  In modern medicine, the disease can be co-related with malabsorption syndrome and also Irritable Bowel Syndrome. There are enormous formulations mentioned in Ayurvedic classics for the augmentation and restoration of Agnibala in general and Grahani in particular. The Mustakarishta is a reputed formulation, mentioned in the Bhaishajya Ratnavali, a classical  text of Ayurveda for the treatment of Ajirna,Agnimandya,Grahani, Visuchika etc.

      As Grahani roga is caused due to agnimandya, the main line of treatment is to correct the agnidusti by administering drugs which are deepana and pachana in nature. The trial drug Mustakarishta is a classical medicine mentioned in Bhaishajya Ratnavali as well as AFI- Part-I, 1:26 (pg. 17) and API Part – II, Vol.II (1^st edition, pg. 45). The Ingredients contain in this trial medicine are  having properties like deepan, pachana and sthambhaka and can able to correct the agnimandya condition and disorders of Purishavaha srotas.  

      So  the aim and object of the present study is planned to evaluate therapeutic efficacy of Mustakarishta in the patients of Grahani along with safety measures by observing adverse events (AE) if any or Adverse drug reaction (ADR). The efficacy of the trial drug would be assessed by observing the improvement in Subjective parameters (Clinical Symptoms). Improvement in WHOQOL score and lab. parameters.