Palmoplantar psoriasis is a localised form of psoriasis which accounts for 3-4% of all psoriasis cases and produces significant functional and social disability. It is a chronic recurring disease which may exist in the absence of psoriasis lesions in other parts of the body. So, a randomised ,double-blind comparative trial is being planned in the Out Patient Department of Department of Dermatology in  KPC Medical College and Hospital, Jadavpur, to compare the effectiveness  and safety of topical Methotrexate 1%gel with urea containing emollient  versus  topical Clobetasol propionate 0.05% ointment with urea containing emollient in mild to moderate palmoplantar psoriasis.

In palmoplantar psoriasis, emollients are used in conjunction with topical therapies provide a promising synergistic remedy. Application of emollients hinders water evaporation from skin, increasing hydration in stratum corneum and consequently reducing scaling and erythema associated with psoriasis. Due to their therapeutic effects that improve patient comfort, emollients are used as an adjunct in topical therapies.

Screening is to be done after obtaining written consent. Eligible patients will be randomised into group A and B, and provided with respective medications in both groups. As there is no significant comparative study  between topical Methotrexate 1% gel and topical Clobetasol propionate 0.05% ointment ,we intend to compare their effectiveness and safety in mild to moderate palmoplantar psoriasis.