Nasotracheal intubation is a specialized procedure performed before surgeries involving oral cavity, pharynx, larynx, maxilla, mandible, neck, cervical spine within its surgical field. Nasotracheal intubation provides better access to these areas and a wider surgical field. Most commonly encountered problem faced during this procedure is epistaxis. To avoid it, nasal cavity has to be prepared adequately. One of the most commonly used method for preparation is topical application of vasoconstrictive agents and lubrication. Many studies have been performed regarding the choice of vasoconstrictors and comparing one with the other. We did not find any literature comparing xylometazoline and adrenaline or comparing two different concentrations of adrenaline, though both these agents have been found to maximally reduce epistaxis. So, we wish to compare between these three topical preparations and conclude the best amongst the three. Following approval by the Institutional Ethics Committee, study would be completed in the period of 18 months. After taking written and informed consent from the patient’s relative, this study would be conducted in adult patients (18-65yrs), of either sex, undergoing elective surgery requiring general anaesthesia with nasotracheal intubation. The incidence and severity of epistaxis would be noted while using three different vasoconstrictors during fiberoptic guided nasotracheal intubation. Also 24 hours post-intubation nasal discomfort and pain would be graded by VAS Score.