The research study entitled “A comparative clinical assessment of healing effect of Apamarga Kshara Taila and Thumari Taila in the management of Diabetic ulcer.” was aimed to evaluate and compare diabetic wound healing effect of Apamarga Kshara Taila and Thumari Taila. Another Objective was to evaluate in vitro antimicrobial effect of both the oils. This trial was summarized in review of literature, including Ayurvedic literature and modern literature of Wound and Diabetic Ulcer.

Drug review comprises classical narration of both medicaments of both the groups. They are: Thumari Taila (Scurinega leucopyrus Willd. & Meull), Apamarga Kshara Taila (Achyrenthus aspera Linn.), Pippali (Piper longum Linn.), Haritaki (Terminalia chebula Retz.), Triphala Kwatha (Decoction of three herbs like, Terminalia bellirica Roxb., Terminalia chebula Retz. and (Embellica officinalis Linn.) and Sanjivani Vati (A herbo mineral preparation). Also, it comprises formulation of both the oils i.e., Thumari Taila and Apamarga Kshara Taila, their pharmaceutical and analytical analysis and microbiological stability study.

In- vitro antimicrobial study consists report of Antibacterial activity of both the oils against S. aureus, E. coli, Pseudomonas aeruginosa and Klebsiella pneumonie in compare to ampicillin. Thumari Taila was reported having anti-bacterial effect against S. aureus. Antifungal assay of both the oils was carried out against Candida albicans, Candida glabrata, Aspergillus and Candida tropicalis in compare to fluconazole. Thumari Taila with dry drug sample was found having anti-fungal activity against Candida albicans, Candida glabrata and Candida tropicalis.

Clinical Study stats the open label comparative clinical study of 80 clinical cases of diabetic ulcer. On the basis of computer-generated random number table, Group A (n=41) cases were treated by applying study drug Apmarga Kshara Taila and Group B (n=39) cases were treated by applying Thumari Taila in diabetic ulcer for 30 days. In both groups, adjuvant drugs like Triphala Kwatha (for local wound cleaning just prior to wound dressing), Pippali Choorna (Piper longum Linn.) (3gm empty stomach with water), Haritaki Choorna (powder of Terminalia chebula Retz.) (6 gm at bed time with Luke warm water) and Sanjivani Vati (125mg each) (four times a day) were given commonly in same dose and duration. All the cases were screened for essential serology, hematology, urology, bio-chemical and radiological investigations prior their enrollment for the study.  The effect of the treatment was assessed on the basis of relief in subjective parameters (odor, peri-wound skin, discharge and pain) and objective parameters i.e., wound size and clinical microbiology. All the cases were followed up for 1 month. The observed results in the study were subjected to statistical calculation to derive final conclusion.  

Discussion of the study was made on all demographic observations, clinical findings and invitro antimicrobial study.  Conclusion of clinical study suggested that both the groups medicaments have shown highly significant effect in healing of diabetic ulcers. Apamarga Kshara Taila has been proven as good as Thumari Taila in relieving subjective criteria like Gandha (odor), Varna (peri-wound skin), Srava (discharge), Vedana (pain) and Akriti (wound size). Both the medicines were also found effective in reducing microbial load of the ulcers and improving unit healing time. From this clinical study, it was concluded that, Apamarga Kshara Taila and Thumari Taila have equal wound healing effect in the management of diabetic ulcers. Hence alternate hypothesis (H₁) is rejected and null hypothesis (H₀) is accepted i.e., there is no difference between healing effects of Apamarga Kshara Taila and Thumari Taila in the management of Diabetic ulcers.