From the early 1970s laparoscopic procedures became well established because of its advantages like reduced post operative pain, improved cosmesis, reduced hospital stay.

Despite its advantages, laparoscopic surgeries have its own demerits due to pneumoperitoneum and positional changes. Pneumoperitoneum causes alteration in cardiorespiratory physiology like reduced thoracopulmonary compliances, reduced functional residual capacity(FRC), increased arterial pressures, increased systemic vascular resistance and pulmonary vascular resistance. Plasma catecholamines and vasopressin levels increases during pneumoperitoneum which is associated with changes in total peripheral resistance. Trendelenburg position and Carbon dioxide(CO₂) causes hemodynamic stress.

Various pharmacological agents like nitroglycerine, beta blocker, magnesium sulphate and opioids are used to provide hemodynamic stability during pneumoperitoneum with their own limitations.

Alpha-2 (α₂) adrenergic agonists have shown the promising result in maintaining the baseline hemodynamic parameters during laparoscopic surgeries with minimal adverse effects. Alpha-2 (α2) adrenergic agonists are useful in attenuating the hemodynamic responses produced by pneumoperitoneum. But not many studies have been done studying the comparative effect of these two drugs especially in laparoscopic onco-surgeries. Hence this study is being taken up to compare intravenous dexmedetomidine and clonidine on haemodynamic response in laparoscopic lower abdominal onco-surgeries.