Negative Pressure wound therapy with instillation provides an additional dimension with the ability to deliver a solution to the wound bed in a preprogrammed manner. The goal of wound management is to create an environment that is conductive to wound healing by decreasing the bacterial bio burden and improving perfusion to the wound. NPWT instillation combines NPWT and timed delivery of topical irrigation solutions. The addition of an instilled irrigating fluid to NPWT provides a unique autolytic and mechanical debridement effect that appears to enhance wound healing over our traditional standard of care for these complex, infected wounds. To test the benefits of antimicrobial instillation in conjunction with NPWT, RCT study was designed to explore the use of VAC therapy plus the intermittent delivery of an instilled antimicrobial topical solution and its effectiveness in treating complex, infected wounds. The reduction in microorganisms, days to wound closure and reduction in surface area of wound were established as endpoints that would best measure the effectiveness of NPWT instillation therapy. It was hypothesized that enhanced reduction in bacterial bio burden would lead to quicker wound closure and patient discharge, resulting in hospital cost savings and reduced patient expense