Trigeminal neuralgia (TGN) is characterized by the sudden onset of recurrent severe pain in trigeminal nerve distribution. The condition is severely disabling with impaired quality of life. Idiopathic TGN is difficult to treat by medications and interventional therapy may be required in 25-30% of patients. Trigeminal nerve block is usually performed for the relief of severe refractory pain of TGN by using landmark technique or under fluoroscopy guidance. The ultrasound-guided trigeminal nerve block via pterygopalatine fossa has been demonstrated in few case reports and found to be effective in patients with refractory trigeminal neuralgia and atypical facial pain. Therefore, the present study has been planned to evaluate the feasibility and effectiveness of ultrasound-guided trigeminal nerve block via pterygopalatine fossa for the management of idiopathic trigeminal neuralgia. In this study, 40 consecutive patients of refractory trigeminal neuralgia will receive trigeminal nerve block with 4 mL of bupivacaine 0.25% and 40 mg triamcinolone in the pterygopalatine fossa using ultrasound guidance. The patients will be followed up for 3 months to assess global pain relief and reduction in analgesic medications. Any adverse effect, patients’ satisfaction, and the number of patients having effective pain relief for 3 months will be recorded.