In developed countries, stroke is the most frequent cause of disability among the adults. Due to better medical care of present day scenario, death rate due to stroke has been decreased, but alongside disability due to stroke increased. Unfortunately, the majority of patients with stroke experience incomplete recovery of motor deficits despite intensive rehabilitation, with up to 60% having impaired manual dexterity 6 months following the stroke. Hemiparesis is a serious motor impairment following stroke and affecting around 65% of stroke patients. Currently, the stroke incidence in India is much higher than western industrialized countries. Studies with homeopathic medicines show significant effect in stroke patient. In this prospective, open, randomised, placebo controlled pilot trial at National Institute of Homoeopathy, 60 patients suffering from post-stroke hemiparesis will be randomised in 1:1 ratio into either individualised homeopathic medicines or placebo in the mutual context of standard physiotherapeutic measures. Medical Research Council muscle strength grading scale (MRC muscle scale) will be used as the primary outcome measure and Stroke Impact Scale (SIS) and Modified Ashworth Scale (MAS) as the secondary outcome measures; measured at baseline, and after 3 months. At the end of 3 months, comparative analysis will be carried out to detect group differences, if any. Results will be published in scientific journals.