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CTRI Number  CTRI/2012/12/003232 [Registered on: 17/12/2012] Trial Registered Retrospectively
Last Modified On: 28/02/2013
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   prospective 
Study Design  Other 
Public Title of Study   An observational multicenter study to assess the risk factor profile of early Coronary Artery Disease (CAD) in Indians 
Scientific Title of Study   A prospective observational study to examine the risk factor profile of premature Coronary Artery Disease (CAD) in Indians 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
LA/76/2010  Protocol Number 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr S S Iyengar 
Designation  Cheif Scientific Coordinator 
Affiliation  Scientific Advisor-Lotus Clinical Research Academy Pvt Ltd,  
Address  Lotus Clinical Research Academy Pvt Ltd, 147/F. 8th Main, 3rd block, Koramangala, Bangalore
147/F. 8th Main, 3rd block, Koramangala, Bangalore
Bangalore
KARNATAKA
560034
India 
Phone  09845116933  
Fax  -  
Email  shamiyengar@airtelmail.in  
 
Details of Contact Person
Scientific Query
 
Name  Dr S S Iyengar 
Designation  Cheif Scientific Coordinator 
Affiliation  Scientific Advisor-Lotus Clinical Research Academy Pvt Ltd,  
Address  Lotus Clinical Research Academy Pvt Ltd, 147/F. 8th Main, 3rd block, Koramangala, Bangalore
147/F. 8th Main, 3rd block, Koramangala, Bangalore
Bangalore
KARNATAKA
560034
India 
Phone  09845116933  
Fax  -  
Email  shamiyengar@airtelmail.in  
 
Details of Contact Person
Public Query
 
Name  Dr S S Iyengar 
Designation  Cheif Scientific Coordinator 
Affiliation  Scientific Advisor-Lotus Clinical Research Academy Pvt Ltd,  
Address  Lotus Clinical Research Academy Pvt Ltd, 147/F. 8th Main, 3rd block, Koramangala, Bangalore
147/F. 8th Main, 3rd block, Koramangala, Bangalore
Bangalore
KARNATAKA
560034
India 
Phone  09845116933  
Fax  -  
Email  shamiyengar@airtelmail.in  
 
Source of Monetary or Material Support  
Lotus Clinical Research Academy, No. 582, KCA Enclave, 8th Block, Koramangala Extension, Bangalore 560095  
 
Primary Sponsor  
Name  Lotus Clinical Research Academy 
Address  No. 582, KCA Enclave, 8th Block, Koramangala Extension, Bangalore 560095  
Type of Sponsor  Contract research organization 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 22  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr I Sathya Murthy  Apollo Hospitals  Department of Cardiology, 21. Greams Road, off. Greams Lane,Chennai
Chennai
TAMIL NADU 
04428290200
-
ismuthy@hotmail.com 
Dr Ramamurthy Bingi  Apollo Hospitals  Apollo Hospitals, Department of Cardiology, No. 154/11, Opp. I.I.M., Bannerghatta Road, Bangalore -560 076
Bangalore
KARNATAKA 
09845009192

bingiramamurthy@yahoo.co.in 
Dr S S Ramesh  Bhagwan Mahaveer Jain Heart Centre  Department of Cardiology, No. 8, Millers Road, Vasanth Nagar, Bengaluru-560 052, Karnataka. India
Bangalore
KARNATAKA 
080-22207640
-
trials@cra.co.in 
Dr Rajeev Guptha  Fortis Escorts Hospital  Department of Cardiology, Jawahar Lal Nehru Marg, Malviya Nagar, Jaipur, India
Jaipur
RAJASTHAN 
0141-2547000
-
rajeevgg@gmail.com 
Dr Keshava  Fortis Hospital  Department of Cardiology, No 14, Cunningham Road, Sheriffs Chamber,Bangalore -560052, Karnataka, India
Bangalore
KARNATAKA 
9845033681
-
rkeshava@hotmail.com 
Dr NatarajanS  G.Kuppuswamy Naidu Memorial Hospital  Department of Cardiology, Pappanaickenpalayam, Coimbatore, Tamil Nadu 641037
Coimbatore
TAMIL NADU 
04224305321
-
dr_snrcbe@yahoo.co.in 
Dr C N Manjunath  Jayadeva Institute of Cardiovascular Science and Research,  Department of Cardiology, Jayanagar,9th Block, Bannerghatta Road, Bangalore-560 069
Bangalore
KARNATAKA 
080-22977395
--
director@jayadevacardiology.com 
Drvijaya Raghavan  KIMS Hospital & Research Center  Department of Cardiology, Anamukham,P.B.No.1, Anayara P.O,Thiruvananthapuram - 695 029, Kerala, India
Thiruvananthapuram
KERALA 
0471-2447575
-
cardiology@kimskerala.com 
Dr Thomas Alexander  Kovai Medical Center and Hospital  Department of Cardiology, P.B.No.3209,Avanashi Road,Coimbatore-641014,
Coimbatore
TAMIL NADU 
04224323280
-
tomalex41@gmail.com 
Dr Sameer I Dani  Life Care Institute of Medical Sciences & Research  Department of Cardiology, sardar Patel statue corner, stadium road, Naranpura, Naranpura Vistar, Ahmedabad -380013, India
Ahmadabad
GUJARAT 
09825038855
-
danisameer@hotmail.com 
Dr Ajit Mullasari  Madras Medical Mission  Department of Cardiology, No. 4-A, Dr. J. Jayalalitha Nagar, Mogappair, Chennai - 600 037 Tamilnadu, India
Chennai
TAMIL NADU 
04426561801
-
crdmmm@gmail.com 
Dr S S Iyengar  Manipal Hospitals  Department of Cardiology, No.98, HAL Airport Road, Bangalore -560 017
Bangalore
KARNATAKA 
9845116933
-
shamiyengar@airtelmail.in 
Dr Ramesh Babu  Medwin Hospital  Department of Cardiology, Raghava Ratna Towers, Nampally, Hyderabad - 500 001, Andhra Pradesh, India
Hyderabad
ANDHRA PRADESH 
04023202902
-
medwin_research@yahoo.co.in 
Dr Nagaraj Desai  Namana Medical Center  Department of Cardiology, No.31/1a, Seenappa Layout, New Bel Road,RMV 2nd Stage, Bangalore -560 094
Bangalore
KARNATAKA 
080-23518833

desai_nagaraj@yahoo.co.in 
Dr Narendra  Nanjappa Hospital  Department of Cardiology, Nanjappa hospital, No.660, Kuvempu Road, Shimoga- 577201
Shimoga
KARNATAKA 
08182225085

jncardiology@gmail.com 
Dr Hiremath JS  Poona Hospital & Research Center  Department of Cardiology, 27, Sadashiv Peth, Pune, 411030
Pune
MAHARASHTRA 
02026123391
-
drjagadishhiremath@gmail.com 
Dr Tiny Nair  PRS Hospital  Department of Cardiology, Killipalam,Trivandrum -695002. Kerala, India.
Thiruvananthapuram
KERALA 
04712344442
-
tinynair@gmail.com 
Dr Anne Sheela  PS Mission Hospital  Department of Cardiology, Main Road, Maradu,Ernakulam- 682304, Kerala, India
Ernakulam
KERALA 
09496449801
-
sheela.annie@yahoo.com 
Dr JPS Sawhney  Sir Ganga Ram Hospital  Department of Cardiology, Rajinder Nagar, New Delhi 110060, India
New Delhi
DELHI 
01125750000
-
jpssawhney@yahoo.com 
Dr Arun Srinivas  Sri Vikram Hospital & Heart Care  Department of Cardiology, No. 46, Vivekananda Road, Yadavagiri, Mysore - 570 020, India
Mysore
KARNATAKA 
9845028387
-
arunsrinivas@vhpl.com 
Dr C B Patil  St Johns Medical College and Hospital  Department of Cardiology, John Nagar, Sarjapur Road, Bengaluru - 560 034
Bangalore
KARNATAKA 
9845014311
-
drcbpatil@gmail.com 
Dr Girish Godbole  Vikram Hospitals  Department of Cardiology, No.71/1,Opp to St Annes School And Convent, Millers Road, Bangalore - 560052 India
Bangalore
KARNATAKA 
9845866395
-
drgirish1@gmail.com 
 
Details of Ethics Committee
Modification(s)  
No of Ethics Committees= 22  
Name of Committee  Approval Status 
Ethics committe of Manipal Hospitals/Bangalore/Dr.S.S.Iyengar  Approved 
Ethics committe,Apollo hospitals/Chennai/Dr.I.Satyamurthy  Approved 
Ethics Committe-Poona hospital & Research centre/Pune/Dr.Jagadish Hiremath  Approved 
Ethics Committe-Sir Gangaram Hospitals/New Delhi/Dr.J.P.S.Swahney  Approved 
Fortis Hospital Ethics Committe/Jaipur/Dr.Rajeev Gupta  Approved 
Fortis Hospital-Ethics Committe/bangalore/Dr.Keshawa R  Approved 
IEC Consultants/Bangalore/Dr. Arun Srinivas  Approved 
IEC Consultants/Bangalore/Dr. S S Ramesh  Approved 
IEC Consultants/Bangalore/Dr.dani Sameer Indravadan  Approved 
IEC Consultants/Bangalore/Dr.girish Godbole  Approved 
IEC Consultants/Bangalore/Dr.J.Narendra  Approved 
IEC Consultants/Bangalore/Dr.Mullasari Ajit S  Approved 
IEC Consultants/Bangalore/Dr.Nagaraj Desai  Approved 
IEC Consultants/Bangalore/Dr.Natarajan S  Approved 
IEC Consultants/Bangalore/Dr.Sr. Annie Sheela  Approved 
IEC consultants/Bangalore/Dr.Thomas Alexander  Approved 
IEC consultants/Bangalore/Dr.Tiny Nair  Approved 
IEC Consultants/Bangalore/Dr.Vijayaraghavan G  Approved 
Indepent Ethics Committe-Apollo hospitals/Bangalore/Dr.Ramamurthy Bingi  Approved 
Institutional Ethics Committe-Medwin Hospital/Hyderabad/Dr.B Ramesh Babu  Approved 
sri jayadeva institute ethics committee/Bangalore/Dr.C.N.Manjunath  Approved 
St. Jhons Medical College and Hospital, Institutional Ethical Review Board  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  Risk Factors for CAD,  
 
Intervention / Comparator Agent  
Type  Name  Details 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  All patients included in the study should satisfy the following criteria.
• Age: Male patients who are less than 55 years and female patients who are less than 65 years of age
• Symptomatic for CAD or established CAD by one or all of the methods described in Section 5.1.
• Willing to sign an informed consent
 
 
ExclusionCriteria 
Details  1.Age: Male patients who are greater than 55 years and female patients who are greater than 65 years of age
2. There is an absence of CAD or diagnosis of CAD by other methods than those
• by a definite imaging technique
• symptomatic for CAD and stress test positive

• who have had previous Coronary artery bypass surgery (CABG) or Percutaneous Transluminal coronary angioplasty (PTCA).
or a doubtful diagnosis of CAD.
3. Unwilling to participate in the study or sign the informed consent
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
risk factor profile of premature CAD in young Indian men (below 55 years) and women (below 65 years).   02 years 
 
Secondary Outcome  
Outcome  TimePoints 
1.To assess and examine treatment variables and suggested lifestyle changes across regions pre and post-intervention.
2.To compare the prevalence of MI in the study group based on the old and new classification of MI.
3.To assess outcome with reference to practice pattern.
4.To evaluate adherence to guidelines
 
02 years 
 
Target Sample Size   Total Sample Size="2000"
Sample Size from India="2000" 
Final Enrollment numbers achieved (Total)= ""
Final Enrollment numbers achieved (India)="" 
Phase of Trial   N/A 
Date of First Enrollment (India)   17/12/2010 
Date of Study Completion (India) Date Missing 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="4"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   no publication made till date 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Brief Summary  

This is a multicentre prospective observational study designed to examine the risk factor profile of Coronary Artery Disease in the study cohort of young. This study aims at a better understanding of the risk factors of CAD by examining patients who have an established CAD. Since the major cause of CAD in the younger age group is erratic lifestyle, eating habits and lack of exercise, this study will give a better understanding of the impact of health interventions within the Indian community. This monitoring plan is applicable to the Monitoring team of Lotus Clinical Research Academy Private Limited.

 
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