COMPARATIVE STUDY TO EVALUATE INTRAVENOUS DEXMEDETOMIDINE AND ESMOLOL FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Candidate: Dr. Akshay Kalia

Supervisor:                                               Co-Supervisor:

Dr.Naresh Baghla                                    Dr. Gurpreet Singh

Head of the Department                              Professor,

Dept. of Anaesthesiolgy,                           Dept. of Anaesthesiology     

G.G.S. Medical College,                               G.G.S. Medical College,

Faridkot.                                                 Faridkot.

INTRODUCTION : Securing a patent airway is of paramount importance in the management of any safe anesthetic procedure and it is one of the primary goals of an anaesthesiologist during general anaesthesia Though endotracheal intubation is a perfect airway device yet its placement isknown to evoke the stress response, predominantly in the form of tachycardia and systemic hypertension, exposing the patient to unwanted risk The topic of study will be selected because tachycardia and hypertension may getfurther enhanced in response, to laryngoscope and tracheal intubation, proven dangerous to cardiovascular disease patients.

AIMS AND OBJECTIVESThe present study will be designed 1. to evaluate the effects of Intravenous Dexmedetomidine and esmolol  in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation. 2. to compare the effects of Intravenous Dexmedetomidine and esmolol  in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation

MATERIALS AND METHODS : The present study will be conducted in a randomized manner in the department of Anaesthesiology, GGS Medical College and hospital,Faridkot on 210 adults participants of ASA Grade I & II, aged 18-60 years, schedule to undergo elective surgery under general anaesthesia, will be  randomly allocated to either of the three study groups.GROUP C – will receive 20ml of 0.9% Normal saline infused over a period of 10 min and induction of anaesthesia will be done immediately.GROUP D – will receive Dexmedetomidine 1μ/kg intravenous diluted with 0.9%  normal saline to 20 ml infused over 10 min and induction of anaesthesia will be done immediately.GROUP E – will receive Esmolol 1.5mg/kg intravenous diluted  with 0.9% normal saline to 20ml  infused over 10 min  and induction of anaesthesia will be done immediately.