Osteoarthritis is the most prevalent form of arthritis in India, affecting over 15 million adults every year. It is the disease of old age and by 2020, the number of 65 years and above population in India is likely to be about 177 million. India may become the osteoarthritis capital of the world with over 60 million cases of the diseases by 2025. Despite the advancement in using new drugs and techniques, the management of Osteoarthritis with analgesics, corticosteroids and surgical procedure (total knee replacement) in Allopathic medicine is either temporary or very costly and also having many side effects. Ayurveda is the best alternative option. In Ayurveda, Sandhigata Vata is managed by Snehana, Swedana, Upanaha and Vata Shamak drugs. Among the wide varieties of drugs mentioned in Ayurveda text books, Adityapaka Guggulu and Sandhivatari Gutika have been chosen for the study so as to re-establish their efficacy which may contribute to the successful treatment of Sandhigata Vata (OA). Adityapaka guggulu which has been mentioned invVatavyadhi prakaran of Chakradatta contains triphala, pipplai, tvak, ela and guggulu processed in dashmool kvatha. Similarly, Sandhivatari Gutika which has been mentioned in Uttarkhanda, Amavata Chikitsha of Rasachandansu contains rakta bola, hingula and guggulu. The contents of these drugs are easily available and cheaper. They are easy to use as there is no special measure or precaution that needs to be taken during their administration. The efficacy of these two drugs will be assessed and compared. In both cases Janu Basti with Nirgundi tailam will also be done.