For complete regeneration, delivery of growth factors in the local environment holds a great deal of adjunct to bone grafts. Platelet rich fibrin (PRF) is considered as second generation platelet concentrate, consisting of viable platelets, releasing various growth factors.  Hence, this study aims to investigate the clinical and radiological (bone fill) effectiveness of autologous PRF and synthetic Hydroxyapatite granules in the treatment of periapical defect bony defects.

Aim and Objective: Comparison of the efficacy of PRF and HA bone grafts in periradicular surgery by clinical and radiographic evaluation.

Study Design/Methodology: A randomised clinical trial was conducted in patients who were assigned for periradicular surgery. 20 patients were included in this study and were divided into 2 groups. The patients were randomly assigned for the surgery, received synthetic HA graft and PRF obtained from the patient in the respective assigned groups. A clinical and radiographic evaluation was performed postoperatively at the period of 1 month, 3 months and 6 months.

Results: There was no statistical difference in clinical healing as well as reduction in defect size radiographically in both the groups. Although both the biomaterials were seen to enhance the rate of bone deposition and can be used as an adjuvant in the treatment of periapical defects.

Conclusion: It was concluded from the study that a good quality apical seal can be obtained using root‑end filling materials contributing to the success of the treatment. To further enhance the success rate, grafts, and various host modulating agents can be used. HA crystals used as grafts are bioactive materials that promote the formation of new bone. However, PRF is preferred over grafts as it is autologous and promotes faster healing by release of growth factors needed for the formation of bone