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CTRI Number  CTRI/2018/04/013402 [Registered on: 20/04/2018] Trial Registered Prospectively
Last Modified On: 16/11/2019
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Prospective Observational 
Study Design  Single Arm Study 
Public Title of Study   A study to see the utility of Baska mask (airway device) with regards to management of airway during general anaesthesia 
Scientific Title of Study   A Prospective observational study of Baska mask for airway management during General Anaesthesia. 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Kailash Sharma 
Designation  Professor 
Affiliation  Tata Memorial Hospital 
Address  Dept. of Anaesthesia, Critical Care and Pian, Tata Memorial Hospiatal, Parel, Mumbai

Mumbai
MAHARASHTRA
400012
India 
Phone  02224177044  
Fax    
Email  rashmikailashsharma@yahoo.co.in  
 
Details of Contact Person
Scientific Query
 
Name  Dr Atul Kulkarni 
Designation  Professor 
Affiliation  Tata Memorial Hospital 
Address  Dept. of Anaesthesia, Critical Care and Pian, Tata Memorial Hospiatal, Parel, Mumbai

Mumbai
MAHARASHTRA
400012
India 
Phone    
Fax    
Email  kaivalyaak@yahoo.co.in  
 
Details of Contact Person
Public Query
 
Name  Dr Atul Kulkarni 
Designation  Professor 
Affiliation  Tata Memorial Hospital 
Address  Dept. of Anaesthesia, Critical Care and Pian, Tata Memorial Hospiatal, Parel, Mumbai


MAHARASHTRA
400012
India 
Phone    
Fax    
Email  kaivalyaak@yahoo.co.in  
 
Source of Monetary or Material Support  
Intramural Grant 
 
Primary Sponsor  
Name  TRAC 
Address  Tata Memorial Hospital, Parel, Mumbai - 400012 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Kailash Sharma  Tata Memorial Hospital  OT Floor, 2nd floor, Main Building, Tata Memorial Hospital, Parel, Mumbai 400012
Mumbai
MAHARASHTRA 
02224177044

rashmikailashsharma@yahoo.co.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethics Committee  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied
Modification(s)  
Health Type  Condition 
Patients  (1) ICD-10 Condition: J958||Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified, Patients with ASA status I-II, More than 18 years of age with Mallampati class I-II having a mouth opening more than 3 cm BMI less than 30 kg/m2 ,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Baska mask  After obtaining informed consent from the patients, an appropriate sized Baska mask will be used according to the recommendation of the manufacturer. 
Comparator Agent  None  None 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  1. ASA status I-II
2. >18 years of age
3. Mallampati class I-II
4. Having a mouth opening > 3 cm
5. BMI < 30 kg/m2
6. Elective surface surgery of short duration requiring general anaesthesia.
 
 
ExclusionCriteria 
Details  1. Patients with anticipated difficult airway
2. Current or recent sore throat
3. Gastro-esophagealreflux disease
4. Cervical spine disease
5. Pregnancy
6. Dysphonia or dysphagia.
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
The primary end point of the study will be first attempt success rate of insertion of baska mask  The primary end point of the study will be first attempt success rate of insertion of baska mask 
 
Secondary Outcome  
Outcome  TimePoints 
Number of attempts needed for insertion  At the time of insertion 
 
Target Sample Size   Total Sample Size="100"
Sample Size from India="100" 
Final Enrollment numbers achieved (Total)= "100"
Final Enrollment numbers achieved (India)="100" 
Phase of Trial   N/A 
Date of First Enrollment (India)   02/05/2018 
Date of Study Completion (India) 08/01/2019 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   None Yet 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Brief Summary  

Introduction and Background:

A variety of devices are available for securing the airway during conduct of general anaesthesia, the gold standard being the endotracheal tube. However, it may be replaced with less invasive devices to reduces complications such as glottis trauma, ischemia of the tracheal mucosa with subsequent stenosis to list a few; provided this does not compromise the patient safety.Baska mask is a novel airway device with a self sealing variable pressure cuff which increases proportionately with increasing airway pressure during positive pressure ventilation. It has an insertion tab for manually curving the mask for easy insertion. The large distal aperture locates at the upper oesophagus and opens into the sump cavity for easy drainage of gastric fluid thus minimising the risk of aspiration. The advanced airway opening provides superior patency of seal and increased protection against gastric overflow.

Dr. Archie Bain developed the laryngeal mask airway in 1982 at royal London hospital as a modification of the Goldman dental mask. Supraglottic airway devices in comparison to endotracheal tube reduce the stress response which occurs with laryngoscopy and intubation reduces requirement of anaesthetic agents for airway tolerance, neuromuscular blockade not always necessary for insertion, easier to insert, have a lower incidence of sore throat, it can be easily inserted in patient with cervical spine injury.

Baska mask is a novel airway device which has a self sealing variable pressure cuff which increases proportionately with increasing airway pressure during positive pressure ventilation. The cuff is continuous with the airway channel and gets inflated with positive pressure ventilation. It has an insertion tab for manually curving the mask for easy insertion. It has a large distal aperture which locates at the upper oesophagus and has a sump cavity for easy drainage of gastric fluid thus minimizing aspiration risk. The dorsal surface is made in a way that it directs the oropharyngeal secretions towards the side channel to which suction can be attached. The tube also has a built in bite block.  The proximal end has loops which help in fixation of the mask.

Aim:

The aim of this study is to see the utility of Baska mask with regards to management of airway during general anaesthesia.

 

Study design:

It will be a Prospective observational study

 

Patients and methods:

Patients undergoing surgeries in Tata Memorial Centre over duration of one year will be enrolled in the study. All patients fulfilling the inclusion criteria and after obtaining informed written consent, posted for elective surgery under anaesthesia will be included in the study.

Inclusion criteria: Participating patients should satisfy the following:

1.    ASA status I-II

2.    >18 years of age

3.    Mallampati class I-II

4.    Having a mouth opening > 3 cm

5.    BMI < 30 kg/m2

6.    Elective surface surgery of short duration requiring general anaesthesia.

 

Exclusion criteria:

1.    Patients with anticipated difficult airway

2.    Current or recent sore throat

3.    Gastro-oesophageal reflux disease

4.    Cervical spine disease

5.    Pregnancy

6.    Dysphonia or dysphagia.

 

Sample size:

The literature regarding the use of Baska mask is scarce with first attempt success rates ranging from 72-88%. To detect a first attempt success rate of 80% with 8% precision (range 72% to 88%) at 95% confidence, we will need to study 97 patients. Therefore, we will include 100 patients to allow for protocol violation, lack of data, etc. This study will be done over a period of 12 months.

 

Methodology:

This will be a prospective observational. After obtaining Ethics committee approval and written informed consent, 100 patients will be enrolled.

Participating patients should satisfy following criteria:

1.    ASA status I-II

2.    >18 years of age

3.    Mallampati class I-II

4.    Having a mouth opening > 3 cm

5.    BMI < 30 kg/m2

6.    Elective surface surgery of short duration requiring general anaesthesia.

Following patients will be excluded:

1.    Patients with anticipated difficult airway

2.    Current or recent sore throat

3.    Gastro-esophagealreflux disease

4.    Cervical spine disease

5.    Pregnancy

6.    Dysphonia or dysphagia.

After obtaining informed consent from the patients, an appropriate sized Baska mask will be used according to the recommendation of the manufacturer.

Anaesthesia will be induced with fentanyl 2mcg/kg and propofol 2 mg/kg. Intermediate acting muscle relaxant will be used for muscle paralysis. Hemodynamic parameters- HR, SBP, DBP, MAP, will be measured non-invasively at following intervals: before induction of anaesthesia and every minute up to 5 minutes after induction of anaesthesia. Anaesthesia will be maintained with Sevoflurane/Isoflurane and N2O in 40% oxygen. Tidal volume will be adjusted to keep end-tidal-CO2 concentration between 30-35 mm Hg. The primary end point of the study will be first attempt success rate of insertion of baska mask.

Variables measured will be:

1.    First attempt success rate of insertion of Baska mask.

2.    Overall success rate of insertion of Baska mask.

3.    Number of attempts needed for insertion.

4.    Time required to secure the airway.

5.    Magnitude of hemodynamic response from baseline to up to 5 minutes after insertion.

6.    Adequacy of airway sealing pressure (no leak at 20 cm H2O airway peak pressure or tidal volume 8 ml/kg).

7.    Stability of device intra-operatively. Any displacement or need to reinsert the device intra-operatively.

8.    Need to change over to endotracheal intubation.

9.    Presence of sore throat 1 h our after removal of device.

10. Presence of dysphagia (after giving a few sips of water) 1 hour after removal of device.

11. Any adverse events such as bronchospasm, Laryngospasm or desaturation (<92%) aspiration, regurgitation of gastric contents.

Insertion and positioning: A single operator after achieving the competency in insertion of the airway device will insert the airway in all patients. Airway insertion time will be recorded using a stop watch. Recording will start when the device will be inserted in the patient’s mouth and stop when an adequate airway (as described above) is obtained. The number of attempts required to correctly position the device will be recorded, along with the size used. Once the device is optimally positioned, its position will not be altered unless clinically indicated.

Laryngospasm, if occurs will be recorded.

Airway sealing pressure: After optimally positioning the device, airway sealing pressure will be measured by closing the expiratory valve of the circle system at a fixed gas flow and noting the airway pressure at which the dial on the aneroid manometer reaches equilibrium.

Degree of irritation: One hour post-operatively, patients will be asked about presence of sore throat or dysphagia.

 

Ethical Considerations:

The study will be initiated after obtaining the approval of The Institutional Ethics Committee. Written informed consent will be taken from all participating patients.

 

Statistical analysis:

Since this is an observational study, we will use descriptive analysis to describe success rate. A student’s t test and Chi square test will be used for describing adverse events.

 
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