Kamala is one of the important, common clinical entities in Ayurveda whose description appears to be most comprehensive and incorporates the disorders of Hepato-Biliary system of Modern medicine. In ayurvedic literature Kamla has been mentioned as  sequel of PanduRoga. It occurs when Pandurogi takes more PaitikAahar-Vihar. Jaundice is a yellowish discoloration of tissue resulting from the deposition of bilirubin. These occur only in the presence of serum hyperbilirubinemia and is a sign of liver disorder.             

       ‘‘Suchimukhakrimi” affecting the liver cells directly specifically mentioned in 5^th chapter of HareetSamhita. It can be correlated,thesekrimiswith the viruses those are responsible for Viral Hepatitis. Considering the clinical presentation of Kamala, seems near to hepatitis described in modern medicine. Inflammation of liver (Hepatitis) can be traced to many different causes, including viral infections, alcohol,fat accumulation in the liver,     malunctioning immune system, exposure to chemicals and other toxins and certain drugs.

            Liver is considered to be one of the vital organs which help in maintaining the health of body. Yakrit (liver) is being described right from the Vedic period. Modern lifestyles can over stress the liver and make it malfunctioning. The liver diseases have remained a challenge to medical profession since many of the liver disease may ultimately lead to irreversible changes. Liver function tests along with liver enzymes constitute groups of tests used to determine the state of liver function in a patient. Liver function tests are particularly useful as a screening tool and can be a great benefit when looking for any hepatic dysfunction.                       

            Ayurvedicsystem of medicine recommends various crude drugs for the treatment of hepatic disorders. No significant and safe hepato-protective drugs are available in modern therapeutics which can stimulate the liver function, protect it from damage or help in improving the function of hepatic cells.The nature has bestowed some plants with the property to prevent,treat and cure hepatic disturbances with the interception of fewer side effects.

            Taking into consideration these points polyherbal preparations having an herbal mixture of rare herbs to improve Kamla and liver function named as Liver Tone and Trivrita (Nishotha) Churna have been choosen to seen their effect on the patients of Kamla (Jaundice). So, the clinical study was planned to evaluate the hepatoprotective effect of this herbal formulation.