Vitiligo is a complex metabolic disorder characterized by loss of pigmentation which is polygenic in nature and mostly regarded as social stigma. The course of Vitiligo without treatment is unpredictable. As Vitiligo being most stubborn, resistant cosmetic problem, it needs more attention.  

         Skin sensitivity is genetically predisposed which is usually graded as most sensitive to resistant. Among the subjects with skin grade 1 and 2 the topical application of Unani formulation causes sensitivity problems which ranges from hyperemia, itching, burning, blister formation, etc., which needs formulation that can be well tolerated.

         There is a need to focus on two issues one in combating the origin of disease and the other is to induce the re-pigmentation. The treatment options available across the systems have their own limitation in offering relief to this cosmetic problem. The incidence of side effects are too high as  reported both with topical as well as systemic therapy, at the same time the  surgical options available are self-hazardous unless disease become stable and there  is  hardly any medication available in the modern medicine to control the disease process and to check the aggravation. The steroids and PUVA therapy which are usually employed for the above purpose are Hepato-toxic and carcinogenic in the prolong use.