Chronic sinusitis is one of the most prevalent chronic illnesses all over the world. An estimated 134 million Indians suffer from chronic rhinosinusitis (CRS), 1 in 8 Indians suffer from CRS. According to the, National Ambulatory Medical Care Survey, sinusitis is the fifth most common diagnosis treated with antibiotics. Thus CRS has significant economic implications. The small benefit gained for short duration may be masked by the negative effects of antibiotics and the high recurrence rate of CRS. Homeopathy may hold promise in successful treatment of CRS, but has remained under-researched. In this double-blind, randomized, placebo-controlled, clinical trial at National Institute of Homoeopathy, 62 patients will be randomized to either individualized homoeopathic treatment + saline inhalation (n=31) or indistinguishable placebo + saline inhalation (n=31) to examine whether individualized homoeopathy have any different effect from placebo in treatment of CRS. Sino-nasal Outcome Test 20 (SNOT-20) questionnaire (SNOT-20) scores, EQ-5D-5L scores, and 5 numeric rating scales measuring severity of sneezing, rhinorrhoea, post-nasal drip (PND), facial pain or pressure, and loss of sense of smell will be assessed at baseline, after 2 months, and after 4 months. Comparative analysis will be carried out to examine group differences, if any. Results will be published in scientific journals.