Diabetes is a major lifestyle disorder, prevalence of which has been increasing globally. Insulin resistance, a characteristic feature of Type 2 diabetes is due to reduced response of target tissues, such as skeletal muscle, liver and adipocytes to insulin. Skeletal muscle is the largest insulin-sensitive organ, accounting for more than 80% of insulin-stimulated glucose disposal [1, 2]. Skeletal muscle glucose disposal does not only depend only on its quantity, but also its quality (strength/mass) [3]. Moreover, it is also the quantitatively most dominant tissue with respect to lipid metabolism and the largest glycogen storage organ [4, 5]. Factors regulating fatty acid (FA) oxidation and mitochondrial functional capacity are likely to directly affect muscle metabolic function and, because of its 40% contribution to total body mass, might have a significant impact on whole-body energy metabolism [6]. At resting state itself, skeletal muscle accounts for about 30% of the metabolic rate [7]. Thus, the critical role that skeletal muscle plays in glycemic control and metabolic homeostasis makes it an organ of particular interest in obesity and type 2 diabetes (T2D). Understanding the role and pathogenesis of impaired muscle quality and the metabolic profile in Indian subjects (normal and pre-diabetic) might give insights into the mechanisms driving skeletal muscle glucose disposal in this population, as well as leads for intervention. Studies have shown that intervention involving moderate and high levels of cardiorespiratory fitness provide substantial protection against developing metabolic syndrome. Mechanisms through which exercise modifies chronic disease risk may be mediated by decreases in total and abdominal fat, plasma concentration of lipids, blood pressure, improvements in insulin sensitivity and glycemic control [8]. The focus of this study is to know the most effective exercise prescription for our prediabetic Indian population so as to improve glycemic control by improving the muscle quality and metabolic profile.