Common warts, also called verruca vulgaris is a common dermatological problem, characterized by hyperkeratotic papillomas caused by infection with Human Papilloma Virus (HPV).There are over 118 types of HPV viruses,some of which are implicated in the causation of warts. Warts are of many types and are ubiquitous when it comes to the sites of affection,though they mainly affect the skin of extremities, genital skin and mucosa, larynx and oral mucosa.These are notorious for their infectivity,because any disturbance of epidermal barrier by mild abrasions and maceration is enough to cause infection of the basal keratinocyte with the virus. Spontaneous regression of warts has been seen in two third of cases, yet patients seek treatment because of cosmetic blotch, pain and increase in the number of warts. Many destructive treatment modalities have been explored like topical chemical cautery, cryotherapy, electro-cautery, excision, bleomycin sulphate injection, laser vapourisation and photodynamic therapy ,but none can gurantee a cure and cessation of recurrences.Some of them are costly and can produce side effects like scarring and pain. Considering the fact that despite years of medical research and volumes of literature on this subject, no treatment has yet proven effective for a cure, is exasperating to both the dermatologists’ and patients’ front. In an attempt to overcome the challenges of treatment modalities,as mentioned above,immunotherapy is being researched into as an upcoming and promising field in the treatment of warts.And the rationale behind that being-it has been found that the principal mechanism for the rejection of warts is by cell mediated immunity.Warts can regress when immune response is stimulated and on the other hand it has been noted that prevalence,severity of warts and the incidence of HPV related malignancies increases during the persistant fall of Cell Mediated Immunity(eg HIV). The immunotherapy being researched into are bivalent and quadrivalent HPV vaccines, topical contact sensitizers like Diphencyprone(DPCP), Squaric Acid Dibutyl Ester( SADBE), immunomodifier like imiquimod, antigens like Bacillus Calmette Guerin(BCG), Purified Protein Derivative (PPD), candida, trichophytin, mumps, Mumps-Measles-Rubella(MMR), Mycobacterium w vaccine and interferons.

         The Measles-Mumps-Rubella vaccine is a mixture of live attenuated viruses causing these three diseases, administered via subcutaneous injection to immunocompetant children in two doses with a gap of one month to stimulate their immunity so as to prevent the development of these diseases later on in their life.Intralesional MMR vaccine in the treatment of wart(s) has been found to be effective.