This study is a randomized, double blind, parallel group, active controlled trial to evaluate the efficacy of sugar free chewing gum with and without CPP-ACP in prevention of enamel demineralization around orthodontic brackets. The primary outcome measure is Vickers Hardness measurement of demineralized enamel around orthodontic brackets after 1 month use of interventional and control agents. The secondary outcome measure is to measure the VAS pain score due to chewing the gum in interventional groups in the first week and to identify the number of appliance breakages in one month. The data were analysed statistically. The results of this study showed that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in prevention and remineralization of enamel demineralization. VAS pain scores between intervention and control groups showed statistically significant difference in the pain perceived during the second day after separator placement and first day of activation of the arch wire. There is no statistical significance in the pain perceived during other days. There were no incidences of appliance breakage (debonding of brackets or displacement of arch wire) in gum chewing groups and control group over the period of 30 days.