The clinical presentation of Amavata closely mimics with the special variety of Rheumatologic disorders called rheumatoid arthritis (R.A.). Prevalence of RA is approx. 0.8 % of the population. Due to wide spectrum of disease, much prevalence in the society and lack of effective medicine, the disease had been chosen for the study. Aim- To compare the efficacy of “Shiva Guggulu” and “Alambushadi Ghan Vati” in the management of Amavata (R.A.). Settings and Design: Single Centered, Open Labeled, Randomized Clinical Study. Methods and Material: 50 clinically diagnosed

patients of Amavata and who fulfilled the criteria of inclusion and willing to participate in trial were registered for present clinical trial and divided into two groups by simple randomization method (Lottery method). Group A- 25 patients of Amavata were administered ‘Shiva Guggulu’ 2 Tab (each Tab 500 mg.) thrice in a day with lukewarm water, after meal for 30 days Group B- 25 patients of Amavata were administered ‘Alambushadi Ghan Vati’ 2 Tab (each Tab 500 mg) thrice in a day, with lukewarm water, after meal for 30 days. Statistical analysis used: In Stat Graph Pad 3 Software was used for statistical analysis. For Nonparametric data Wilcoxon matched-pairs signed ranks test while for Parametric data Paired‘t’ Test and for Inter group comparison, Mann-Whitney Test & Unpaired ‘t’ Test were used. Conclusion: On comparing the effect of two therapies it can be concluded that Group B (Alambushadi Ghana Vati) provided better relief statistically than Group A (Shiva Guggulu) in most of the sign and symptom of the disease. It also considerably prevents the relapse.