This split- mouth study was conducted in 30 chronic periodontitis patients with persisting deep periodontal pockets of 30-65 years of age at the Department of Periodontics, Coorg Institute of Dental Sciences Virajpet to evaluate the efficacy of scaling and root planing (SRP) and local drug delivery of 3D Hydrogel containing extracts of Centella Asiatica in chronic generalized periodontitis patients. The 3D gel was applied to pocket base of experimental sites by gently inserting the tip of applicator. Over the following 3 weeks the experimental sites received additional sub-gingival gel administration once a week whereas control site received scaling and root planing. Collection of GCF and plaque sample collection were done at 6, 10, 14, 18 weeks (4months after initial treatment) along with clinical parameters and the samples collected were subjected to BAPNA (Nα-Benzoyl-DL-Arginine-p-Nitroanilide assay) to determine trypsin like activity of Red complex micro-organisms.

 Analysis of variance (One Way Repeated ANOVA) was performed as a parametric test to compare the two groups. The clinical parameters were evaluated by using unpaired t-test.

From the results obtained from this study, all the clinical parameters showed a significant reduction from baseline to 6week in both test (SRP+MED) and control group (SRP alone).

The BAPNA values also showed significant reduction from baseline to 6 weeks when in both groups.

The values of clinical parameters showed a statistically non-significant results when both groups were compared.

There was a reverse trend in both values of clinical and BAPNA values after 10^th week.

Hence, within the limitations of the study, it can be concluded that, 3 D hydrogel as an adjunct to SRP is an effective treatment method but not superior to SRP. Sub-gingivally delivered gel demonstrated a safety profile with no major common untoward allergic, local or systemic effect.