Pain control in dentistry is an important part in reducing the fear and anxiety associated with dental procedures especially in children. Pain on palatal injection is a very commonly experienced symptom in dentistry and as such is a major concern to dentist. A number of techniques may be used to reduce the discomfort of intra-oral injections, the application of topical anaesthetic being a well-known and frequently used option. However, it is effective only on surface tissues (2–3 mm) and tissues deep to the area of application are poorly anesthetized. Surface anaesthesia does allow for atraumatic needle penetration, but because of the density of the palatal soft tissues and their firm adherence to the underlying bone, palatal injection is still painful. Local anaesthetics form the backbone of pain control in dentistry and there has been substantial research for safe and effective local anaesthetic agent. 2% lignocaine is the “gold standard” to which all new local anaesthetics are compared and considered most efficacious anaesthetic agent for use in pediatric and adult patients. Articaine is unique amide local anaesthetics that consist of ester group and thiophene ring which makes it more potent and more lipid soluble and accounts for faster diffusion properties within tissues and bone. Due to this property of diffusion, profound anaesthesia can be achieved on palatal side with buccal infiltration. It has been claimed that articaine is able to diffuse through soft and hard tissues more reliably than other local anaesthetics and that maxillary buccal infiltration of articaine provides palatal soft tissue anaesthesia, obviating the need for a palatal injection which in many hands, is traumatic. Hence, the present study was conducted to evaluate clinically the anesthetic efficacy of only buccal infiltration anesthesia using 4% articaine with buccal plus palatal infiltration using 2% lignocaine for extractions of deciduous maxillary teeth.