Mankind has been affected by renal calculi since centuries, and has been the silent cause of renal failure also. In India the disease affect all age group, source of morbidity 80% those with Renal calculi  are man,⁽⁶⁾ approximately 5-7 million patients suffer from Renal calculi  disease and at least 1/1000 of Indian population need hospitalization due to Renal calculi disease. Thus the disease is a wide spread, particularly in countries with dry, hot climate, these” stone belt regions ”of the world are located in countries of middle east, North Africa , the Mediterranean region, North Western states of India and Southern states of USA and area around the great lakes. In India, the stone belt occupied parts of Maharashtra, Gujarat, Punjab, Haryana, Delhi, Rajasthan etc .In these regions the disease is so prevalent that most of the family will suffer from Renal calculi sometime in their lives.⁽⁷⁾

There is no any specific medical treatment for renal calculi in modern medicine. None of modern methods have provided the final solution for renal calculi. So in this condition most effective and curative treatment is required.

  In Ayurveda various formulation are mentioned for the Mootrashmari management viz. Kshara (Paniya Kshara) ⁽⁸⁾ etc.as it mentioned in Ayurvedic text that kshara has guna karma of chedna, bhedna, lekhna.⁽⁹⁾so, it  have been used effectively and economically on Mootrashmari. No research found on evaluate effect of Gaumutradi kshara in the management of Mootrashmari So,study on “Effect of Gaumutradi kshara in the management of Mootrashmari w.s.r to Renal calculi” is undertaken.