Propofol is the most frequently used IV anaesthetic today. Propofol, when  used for induction of anaesthesia in brief  procedures, results in a significantly  quicker  recovery  and  an  earlier  return  of  psychomotor  function  compared  with  other  induction  agents.  Induction  ofanaesthesia  is associated with several  side  effects with pain during intravenous injection being major among them. In view of  the  above  consideration,  this  clinical  study  was  performed  to  assess  the  comparative effects of 0.5% dilution of propofol MCT/LCT with 0.5% dilution of propofol LCT on injection pain.

A  hundred  ASA  physical  status  I  &  II  patients ,aged 6-12 years,  both  male  and  female  posted for various elective surgeries under general anaesthesia were studied. 

         The patients were divided into two groups of fifty each:

         Group LCT &Group MCT/ LCT (N = 50 ), according to the computer generated list.

         Group LCT received  0.5% dilution of propofol (LCT) at 2mg/kg 

     Group MCT/ LCT received 0.5% dilution of propofol (MCT LCT) at 2mg/kg

 Pain on propofol injection was assessed using Mc Crirrick and Hunter scale of evaluation of propofol  injection pain.The patients  in  both groups were comparable with  respect  to  demographic  and  hemodynamic parameters.Our study showed that 66% of group MCT/LCT and 12% of group LCT had no pain at all. While 8% in group MCT/LCT and 4% in group LCT had mild pain. The patients who experienced moderate pain were 18% in group MCT/LCT and 54% in group LCT,while only 8% had severe pain in group MCT/LCT compared to 30% in group LCT The difference in pain on injection was significantly less in group 0.5% MCT/LCT compared to group 0.5%  LCT with P value of 0.0000 being highly significant. Hence we can conclude that using 0.5% dilution of propofol MCT/LCT has significantly reduced the incidence,intensity and severity of pain on propofol injection.