In Ayurveda  Asmari (Urolithiasis) is well described in Charaka, Susrutha Samhitha with its etiopathogenesis, clinical features, type and prognosis. Vagbhata explained ashmari as one of the Asta maha gada. Asmari has been derived from the “Asman” Sanskrit word which literally means a structure resembling stone. It has been described that due to unwholesome diet and living habits aggravated kapha reaches in urinary tract dries up and forms the calculus and suppression of urge to passing urine resulting in crystallization and precipitate into calculus formation. There is colicky pain in bladder, anorexia, dysuria, fever, physical lassitude, goat like smell in urine and an excruciating pain in the neck of the bladder, scrotum indicate the formation of the urinary calculus. In Vataja variety stone resembles dusky in colour, hard, irregular, rough, nodular and spiny like kadambha flower & Patient feels severe pain, difficulty in passing urine, flatulus and stool. In pittaja variety stone resembles Marking nut seed shape, Yellowish black, blood mixed, honey coloured and patient feels burning sensation, warm feeling over bladder and sucking type of pain. In kaphaja variety stone resembles madhuka puspa in colour, unctuous, large sized like hen’s egg & patient feels dysuria, prickling and incising pain and heaviness and cold sensation over bladder region. On this disease a  series of clinical Research Trials have been conducted for the evaluation of certain medicinal preparations in different stages of the disease effectively with Hajarulayahuda Bhasma, Pashanabhedadi ghrita, Kulattadi yoga, Vvarunadi kwatha, Pashanabhedadi kwatha, Ashmari hara kwatha, gokshuradi guggulu etc. This study has been planned to evaluate the efficacy and safety of  Shvadamshtradi Kashaya and Hajarulayahuda bhasma. These drugs will be given for 12 weeks. This study will be conducted at OPD of Regional Ayurveda Research Institute for Skin Disorders, Vijayawada.