Depression is the most common mental disorder in community settings, and is a major cause of disability across the world. In 1990, it was the fourth commonest cause of loss of disability adjusted life years in the world, and by 2020, it is projected to become the second commonest cause. A range of therapeutic approaches are available, the most widely used, in developed countries, is antidepressant drugs. Still, there still remain flaws in the treatment of depression with antidepressants, in terms of efficacy, adverse effects, toxicity overdose, non-compliance to treatment and delayed onset of their therapeutic response. Use of homeopathy to treat psychiatric problems is widespread, and the need for more high quality controlled trials has been identified. Meta-analyses and systematic reviews have drawn mixed conclusions as to whether homeopathy is more effective than placebo in general medicine. The authors undertook a cross-sectional validation survey, followed by open, observational trial involving 60 patients suffering from geriatric depression in the geriatric outpatient of Midnapore Homeopathic Medical College & Hospital (MHMC&H), Govt. of West Bengal, India from May 2015 to April 2016 using Geriatric Depression Scale (GDS). After 3 months of treatment, moderate to large effect size was observed and the questionnaire psychometrics appeared satisfactory. The authors intend to undertake a multicenter placebo-controlled double-blind randomized efficacy trial of individualized homeopathic treatment on minimum 150 patients suffering from geriatric depression at Midnapore Homoeopathic Medical College and Hospital (MHMC&H), Mahesh Bhattacharyya Homoeopathic Medical College and Hospital (MBHMC&H); and The Calcutta Homoeopathic Medical College and Hospital (CHMC&H). We hypothesize that individualized homeopathic treatment may produce effect significantly different from placebo in treatment of geriatric depression. The outcome measures are Geriatric depression score questionnaire and Quality of Life Scale score questionnaire, to be measured at baseline and after 3 months. Intervention is planned as administering indicated homeopathic remedies in centesimal potencies or placebo, indistinguishable from verum. The generated results will be analyzed in the end using appropriate statistical tests and the results will be published in scientific research journals.