This randomized clinical trial was conducted to observe the efficacy of reflexology therapy in addition to anti-epileptic drugs (AEDs) in treating patients suffering from intractable epilepsy. The hypotheses of hand- and foot- reflexology therapy were respectively to produce results similar to that of vagus nerve stimulations and to maintain homeostasis in the functional status among the body parts. All the subjects taken part in this clinical trial were recruited from the out patients department of Neurology, All India Institute of Medical Sciences (AIIMS). Training on reflexology therapy and monitoring the therapy compliances were performed in the department of Biophysics, AIIMS. The patients were surgically failures or not candidates for palliative epilepsy surgery or non-responders of AEDs. Intractable epilepsy patients were defined as the subjects who had been suffering for a duration of more than 2 years, having seizure frequency at least 2 seizures per month and not responding to at least two anti-epileptic drugs (AEDs) on adequate doses with good compliances. The trial could be completed in a group of 84 patients who had been randomly assigned into two groups. Both control and active group subjects continued on their respective ongoing AEDs. The active group patients received hand- and foot -reflexology therapy in addition. Amongst the types of epilepsy, the observed ones were dyscognitive seizures,  evolving to  bilateral, convulsive seizures (involving tonic, clonic, or tonic and clonic components) and others which included partial seizure, general motor seizure and Lennox Gastaut Syndrome. For the active group patients, reflexology therapy was applied following a pre-determined therapy protocol in a staged manner for an average duration of 2½ months with periodic monitoring of the therapy application compliances. Patients got the reflexology therapy applied by their caregivers at their desired places. During this training period, the patients and their caregivers were presented at the reflexology laboratory for the following purposes: (i) to get the caregivers trained on a particular step of reflexology therapy, (ii) to monitor the response of reflexology therapy, if there developed any adverse effect, and (iii) to assess the quality assurance of the compliances. Patients were asked to apply reflexology therapy on feet 2 times per day. Stimulations on the reflexology areas of the vagus nerve, which were mapped on hands, were produced by the thumb-nail of the patients/caregivers. This process was prescribed for 5 sessions per day with 15 stimulations of ~20 seconds’ duration per session.  The follow-up period of each subject started from the day of 1st therapy session administered and it was 1½ year irrespective of the group. During this follow-up period, the active group patients were asked to report at the laboratory at least once per week for the initial period of 2½ months; 2 times per months for a period of next 6 months; and thereafter once in a month. Identical procedure was followed for the control group patients also. Though the follow-up period was 1 year 6 months, reflexology therapy was advised to be continued up to the next 3years 6 months once per day with the hypothesis of avoiding regeneration of the epileptic foci. The primary outcome measures were to determine (i) the % of reduction in seizure frequency at the end of the follow-up period with respect to the baseline; and (ii) improvement in the quality of life in epilepsy. The secondary outcomes were to detect the knee/lower limb pain (measured by using visual analogue scale) and other associated symptoms by the reflexology method; and accordingly reflexology therapy was applied. Data records on seizure frequency were collected from the seizure diaries maintained by the caregivers.  Reduction in seizure frequency in both groups was compared using Wilcoxon non-parametric test. Within the group, the parameters were compared by two sided Wilcoxon Sign test. The quality of life was assessed by using QOLIE-31 instrument and the data was statistically analyzed using paired sample T-test. The median seizure frequency (number of seizures/month) in control group reduced from 18(range 2-700) to 16(range 2-700). These data for active group were 12(range 2-800) and 2(range 0-210) respectively. There was 87.5% reduction in seizure frequency in the active group (p-value < 0.001). The pre-therapy scores of the quality of life in epilepsy for control and active groups were 41.05±7 and 43.6±8 respectively. The respective post-therapy data were 49.07±6 and 65.4 ± 9. The comparative data were statistically significant with p-value of 0.002. In the group of evolving to bilateral, convulsive seizures, the excellent response (75%≤Response≤100%) was among 76.9% patients. The excellent responses were found to be 54.5% and 50% among the dyscognitive seizures and other types of seizures respectively. Using reflexology techniques, it was possible to detect the internal organ dysfunctions by observing certain external features on the feet and hands. The abnormalities observed on the reflexology areas were tenderness, pigmentation, swelling, hollowness, scaly skin, reoccurrence of corn or callus formation etc. (if it was not due to the misfit of foot wares). By this method, it was observed that 86% of the active group patients suffered from lower limb pain with a p-value<0.001. Post-therapy data revealed that 84% patients responded with 81% reduction in pain severity (p-value<0.001). Other associated symptoms viz., urinary disorders and blood pressure were also improved with statistical significance (p-value<0.05). It was also revealed that there were changes in (i) hoarseness (1 patient), (ii) vomiting (1 patient) and (iii) voice change (2 patients) that developed during the trial period in 4 patients of the active group. These observations were similar to the findings of directly implanted Vagus Nerve Stimulations as reported by vagus nerve stimulation study group. The observations of this clinical trial brought out with the possibility that acupressure hand- and foot- reflexology therapy together with AEDs may be useful for treating patients with intractable epilepsy especially evolving to bilateral, convulsive seizures and dyscognitive seizures. However, a multi-centre study is required to validate all the observations of this phase-II clinical trial.