Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. PRF, as a physiologic fibrin matrix, serves as a net to stem cells, especially when an accelerated angiogenesis develops in the fibrin membrane .This aspect is of particular interest in the case of wide osseous defects.Ultrasound imaging is an easy and reproducible technique that has the potential to supplement CR or DR in the diagnosis of periapical lesions. Ultrasound as a diagnostic tool has been widely used in many medical fields, and its applications in dentistry have not been sufficiently explored¹.The present study was done to evaluate healing after periapical surgery using PRF in one group as an autologous scaffold to fill the bony cavity and leaving the cavity without scaffold in the other group and the healing was comparatively evaluating  by color power doppler ultrasonography after one, three and six months postoperatively. PRF used in this study was prepared using Choukroun’s technique. Choukroun’s platelet-rich fibrin (PRF) (David M. Dohan Ehrenfest 2010) is defined as an autologous leukocyte and platelet-rich fibrin (L-PRF) biomaterial. The PRF membranes release high quantities of growth factors (such as transforming growth factor TGFb-1, platelet-derived growth factor PDGF-AB or vascular endothelial growth factor VEGF) and matrix proteins (such as thrombospondin-1, fibronectin, vitronectin). In all the clinical applications, PRF has to be considered and used as a fibrin-based living biomaterial, and not only as a simple source of growth factors.²⁶